You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KLHL7
Kelch-like protein 7

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322275
  • ENSP00000323270
  • ENSG00000122550
  • ENST00000339077
  • ENSP00000343273
  • ENST00000409689
  • ENSP00000386263
  • ENST00000410047
  • ENSP00000386999

Symbol
  • CISS3
  • KLHL6
  • SBBI26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
protein domain
0.92
disease perturbation
0.87
transcription factor binding site profile
0.81
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
MSRB3
Tbio
Family:  Enzyme
Novelty:  0.02843512
p_int:  0.999999977
p_ni:  2.2e-8
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.9999986
p_ni:  0.0000014
Score:  0.702
Data Source:  BioPlex,STRINGDB
KLHL6
Tbio
Novelty:  0.1573847
p_int:  0.999998445
p_ni:  0.000001554
p_wrong:  1e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999988226
p_ni:  0.000011774
Score:  0.173
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.999649249
p_ni:  0.000176517
p_wrong:  0.000174234
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999270053
p_ni:  0.000729869
p_wrong:  7.8e-8
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.998847145
p_ni:  0.00115285
p_wrong:  5e-9
Data Source:  BioPlex
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.994135887
p_ni:  0.005407248
p_wrong:  0.000456865
Score:  0.207
Data Source:  BioPlex,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
p_int:  0.98834235
p_ni:  0.000646015
p_wrong:  0.011011635
Score:  0.251
Data Source:  BioPlex,STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
Score:  0.656
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
1
1.1
82.2
C-reactive protein measurement
1
1
1
47.7
1
1
0
3.9
36.9
electrocardiography
1
1
2
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
82.2
C-reactive protein measurement
1
47.7
0
3.9
36.9
electrocardiography
2
4.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 7
VGNC:4411
472311
Macaque
kelch like family member 7
705349
Mouse
MGI:1196453
52323
Rat
RGD:1305564
362303
Dog
kelch like family member 7
VGNC:42476
475255
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 7
Macaque
kelch like family member 7
Mouse
Rat
Dog
kelch like family member 7
Publication Statistics
PubMed Score 21.35
PubMed score by year
PubTator Score 19.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title