Tbio KLHL7 Kelch-like protein 7

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q8IXQ5
• A4D144
• B7Z5I9
• G5E9G3
• Q7Z765
• Q96MV2
• Q9BQF8
• Q9UDQ9

Gene Name

• KLHL7

Ensembl ID

• ENST00000322275
• ENSP00000323270
• ENSG00000122550
• ENST00000339077
• ENSP00000343273
• ENST00000409689
• ENSP00000386263
• ENST00000410047
• ENSP00000386999

Symbol

• CISS3
• KLHL6
• SBBI26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
protein domain	0.92
disease perturbation	0.87
transcription factor binding site profile	0.81
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.99   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.99   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0