Tbio KLHL7 Kelch-like protein 7

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q8IXQ5
• A4D144
• B7Z5I9
• G5E9G3
• Q7Z765
• Q96MV2
• Q9BQF8
• Q9UDQ9

Gene Name

• KLHL7

Ensembl ID

• ENST00000322275
• ENSP00000323270
• ENSG00000122550
• ENST00000339077
• ENSP00000343273
• ENST00000409689
• ENSP00000386263
• ENST00000410047
• ENSP00000386999

Symbol

• CISS3
• KLHL6
• SBBI26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
protein domain	0.92
disease perturbation	0.87
transcription factor binding site profile	0.81
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (71)

Explore Interacting Targets

1 – 10 of 71

• See Interactions on String-DB

MSRB3

Tbio

Family:  Enzyme

Novelty:  0.02843512

p_int:  0.999999977

p_ni:  2.2e-8

p_wrong:  1e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

CUL3

Tbio

Novelty:  0.0028737

p_int:  0.9999986

p_ni:  0.0000014

Score:  0.702

Data Source:  BioPlex,STRINGDB

KLHL6

Tbio

Novelty:  0.1573847

p_int:  0.999998445

p_ni:  0.000001554

p_wrong:  1e-9

Score:  0.33

Data Source:  BioPlex,STRINGDB

NUP50

Tbio

Novelty:  0.03424725

p_int:  0.999988226

p_ni:  0.000011774

Score:  0.173

Data Source:  BioPlex,STRINGDB

ACTB

Tbio

Novelty:  0.00006048

p_int:  0.999649249

p_ni:  0.000176517

p_wrong:  0.000174234

Data Source:  BioPlex

ARIH1

Tbio

Family:  Enzyme

Novelty:  0.0258739

p_int:  0.999270053

p_ni:  0.000729869

p_wrong:  7.8e-8

Data Source:  BioPlex

SDC2

Tbio

Novelty:  0.00597758

p_int:  0.998847145

p_ni:  0.00115285

p_wrong:  5e-9

Data Source:  BioPlex

CARNMT1

Tbio

Family:  Enzyme

Novelty:  0.28121779

p_int:  0.994135887

p_ni:  0.005407248

p_wrong:  0.000456865

Score:  0.207

Data Source:  BioPlex,STRINGDB

STAT5A

Tchem

Family:  TF

Novelty:  0.00074026

p_int:  0.98834235

p_ni:  0.000646015

p_wrong:  0.011011635

Score:  0.251

Data Source:  BioPlex,STRINGDB

TOPORS

Tbio

Family:  Enzyme

Novelty:  0.03910082

Score:  0.656

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

UniProt (1)

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1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
UniProt	Protein modification; protein ubiquitination.	399 targets

Name	Explore in Pharos	Explore in Source
Protein modification; protein ubiquitination.	399 targets

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (2)

Components (7)

Processes (1)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	4	3	1	1.1	82.2
C-reactive protein measurement	EFO_0004458	1	1	1		47.7
endometriosis	EFO_0001065	1	1	0	3.9	36.9
electrocardiography	EFO_0004327	1	1	2		4.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	1	1.1	82.2
C-reactive protein measurement	EFO_0004458	1		47.7
endometriosis	EFO_0001065	0	3.9	36.9
electrocardiography	EFO_0004327	2		4.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Kelch repeat
Nucleus
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
electrocardiography
endometriosis
Parkinson's disease

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kelch like family member 7	VGNC:4411	472311
Macaque	kelch like family member 7		705349
Mouse	kelch-like 7	MGI:1196453	52323
Rat	kelch-like family member 7	RGD:1305564	362303
Dog	kelch like family member 7	VGNC:42476	475255

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kelch like family member 7
Macaque	kelch like family member 7
Mouse	kelch-like 7
Rat	kelch-like family member 7
Dog	kelch like family member 7

Publication Statistics

PubMed Score 21.35

PubMed score by year

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PubTator Score 19.15

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (10)

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10

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PMID	Year	Title