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Tbio
KLHL6
Kelch-like protein 6

Protein Summary
Description
Involved in B-lymphocyte antigen receptor signaling and germinal center formation. This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341319
  • ENSP00000341342
  • ENSG00000172578
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell line
0.63
tissue sample
0.6
virus perturbation
0.59
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
KLHL7
Tbio
Novelty:  0.0522116
p_int:  0.999998445
p_ni:  0.000001554
p_wrong:  1e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
RC3H2
Tbio
Novelty:  0.10893793
p_int:  0.999986924
p_ni:  0.000013063
p_wrong:  1.3e-8
Score:  0.458
Data Source:  BioPlex,STRINGDB
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.998818951
p_ni:  0.001181049
Score:  0.193
Data Source:  BioPlex,STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.986118547
p_ni:  0.013881451
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.636
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.613
Data Source:  STRINGDB
SASH3
Tdark
Novelty:  0.37506937
Score:  0.587
Data Source:  STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
Score:  0.586
Data Source:  STRINGDB
MCF2L2
Tbio
Novelty:  0.0545344
Score:  0.58
Data Source:  STRINGDB
GPR174
Tchem
Family:  GPCR
Novelty:  0.09139622
Score:  0.561
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
1
1
1
59.6
birth weight
1
1
1
8.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
1
59.6
birth weight
1
8.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 6
VGNC:6354
735440
Macaque
kelch like family member 6
705455
Mouse
MGI:2686922
239743
Rat
RGD:1307521
287974
Dog
kelch like family member 6
VGNC:42475
488096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 6
Macaque
kelch like family member 6
Mouse
Rat
Dog
kelch like family member 6
Publication Statistics
PubMed Score 7.34
PubMed score by year
PubTator Score 7.40
PubTator score by year
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Related Publications
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PMID
Year
Title