Tbio KLHL42 Kelch-like protein 42

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.

Uniprot Accession IDs

• Q9P2K6
• Q2VPK1
• Q8N334

Gene Name

• KLHL42

Ensembl ID

• ENST00000381271
• ENSP00000370671
• ENSG00000087448

Symbol

• KIAA1340
• KLHDC5
• Ctb9
• KLHDC5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.85
kinase perturbation	0.84
histone modification site profile	0.78
protein domain	0.73
transcription factor binding site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.4   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.4   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0