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Tbio
KLHL41
Kelch-like protein 41

Protein Summary
Description
Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284669
  • ENSP00000284669
  • ENSG00000239474

Symbol
  • KBTBD10
  • KRP1
  • Krp1
  • KBTBD10
  • SARCOSIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.66
cell line
0.65
cellular component
0.65
biological process
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (341)
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.999989594
p_ni:  4.4e-8
p_wrong:  0.000010362
Score:  0.431
Data Source:  BioPlex,STRINGDB
TRIM10
Tbio
Novelty:  0.27685659
p_int:  0.999660903
p_ni:  2.9e-7
p_wrong:  0.000338807
Score:  0.209
Data Source:  BioPlex,STRINGDB
UTP11
Tbio
Novelty:  0.20711838
p_int:  0.999620533
p_ni:  0.000001121
p_wrong:  0.000378346
Score:  0.513
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.965
Data Source:  STRINGDB
RCHY1
Tbio
Novelty:  0.01853663
Score:  0.954
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.945
Data Source:  STRINGDB
KBTBD13
Tbio
Novelty:  0.09921158
Score:  0.942
Data Source:  STRINGDB
ASB11
Tdark
Novelty:  0.84862254
Score:  0.941
Data Source:  STRINGDB
ASB4
Tbio
Novelty:  0.09903118
Score:  0.937
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
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Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kelch like family member 41
706047
Mouse
MGI:2683854
228003
Rat
RGD:620852
117537
Zebrafish
ZDB-GENE-081105-22
100148315
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kelch like family member 41
Mouse
Rat
Zebrafish
Publication Statistics
PubMed Score 28.03
PubMed score by year
PubTator Score 10.08
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title