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Tdark
KLHL36
Kelch-like protein 36

Protein Summary
Description
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258157
  • ENSP00000258157
  • ENSG00000135686
  • ENST00000564996
  • ENSP00000456743

Symbol
  • C16orf44
  • C16orf44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
small molecule perturbation
0.69
histone modification site profile
0.6
tissue sample
0.58
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.11   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.11   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
EIF1AY
Tdark
p_int:  0.999999767
p_ni:  2.33e-7
Data Source:  BioPlex
HMGN2
Tbio
Novelty:  0.0080343
p_int:  0.999999432
p_ni:  5.68e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
HMGN4
Tdark
Novelty:  0.01498794
p_int:  0.999998407
p_ni:  0.000001593
Data Source:  BioPlex
PDAP1
Tbio
Novelty:  0.22387099
p_int:  0.999997797
p_ni:  0.000002198
p_wrong:  5e-9
Data Source:  BioPlex
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.999997329
p_ni:  0.000002671
Score:  0.15
Data Source:  BioPlex,STRINGDB
HMGN1
Tbio
Novelty:  0.00492501
p_int:  0.999995913
p_ni:  0.000004086
p_wrong:  1e-9
Data Source:  BioPlex
PAPLN
Tbio
Novelty:  0.06871524
p_int:  0.999980037
p_ni:  0.000019963
Score:  0.23
Data Source:  BioPlex,STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
p_int:  0.999976159
p_ni:  0.000023841
Score:  0.345
Data Source:  BioPlex,STRINGDB
ITM2A
Tbio
Novelty:  0.06374858
p_int:  0.999935929
p_ni:  0.000064071
Score:  0.177
Data Source:  BioPlex,STRINGDB
AAR2
Tbio
Novelty:  0.05805748
p_int:  0.999699747
p_ni:  0.000300253
Score:  0.186
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
7
79.3
reticulocyte measurement
3
3
4
78.8
lymphocyte count
4
1
4
75.9
myeloid white cell count
1
1
1
74.8
monocyte count
1
1
1
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
79.3
reticulocyte measurement
4
78.8
lymphocyte count
4
75.9
myeloid white cell count
1
74.8
monocyte count
1
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 36
VGNC:13726
454286
Macaque
kelch like family member 36
715423
Mouse
MGI:2385305
234796
Rat
RGD:1561366
498957
Dog
kelch like family member 36
VGNC:42469
489679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 36
Macaque
kelch like family member 36
Mouse
Rat
Dog
kelch like family member 36
Publication Statistics
PubMed Score 1.11
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title