Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Q8N239

Gene Name

KLHL34

Ensembl ID

ENST00000379499
ENSP00000368813
ENSG00000185915

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92

cell type or tissue	0.77

cell line	0.53

chemical	0.41

PubMedID	0.38

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.83 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 29 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.83 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 29 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (66)

Explore Interacting Targets

1 – 10 of 66

See Interactions on String-DB

HSPA8

Tchem

Novelty: 0.00081014

p_int: 0.990645996

p_ni: 0.009354004

Data Source: BioPlex

STUB1

Tbio

Family: Enzyme

Novelty: 0.00055102

p_int: 0.987572256

p_ni: 0.012427744

Score: 0.196

Data Source: BioPlex,STRINGDB

BAG1

Tbio

Novelty: 0.00285515

p_int: 0.949836843

p_ni: 0.04935478

p_wrong: 0.000808377

Score: 0.179

Data Source: BioPlex,STRINGDB

HSPA2

Tchem

Novelty: 0.01696667

p_int: 0.937995065

p_ni: 0.062004935

Score: 0.531

Data Source: BioPlex,STRINGDB

BAG3

Tbio

Novelty: 0.0042967

p_int: 0.922000882

p_ni: 0.077999118

Score: 0.168

Data Source: BioPlex,STRINGDB

HSPA1B

Tbio

Novelty: 0.01429214

p_int: 0.88162142

p_ni: 0.11837858

Score: 0.275

Data Source: BioPlex,STRINGDB

STIP1

Tbio

Novelty: 0.00590952

p_int: 0.856947299

p_ni: 0.143052701

Score: 0.165

Data Source: BioPlex,STRINGDB

HSPA6

Tbio

Novelty: 0.00654285

p_int: 0.796959829

p_ni: 0.203040171

Score: 0.155

Data Source: BioPlex,STRINGDB

CCT2

Tbio

Novelty: 0.01967139

p_int: 0.767377052

p_ni: 0.232622948

Data Source: BioPlex

SMPX

Tbio

Novelty: 0.05084864

Score: 0.788

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular space	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	kelch like family member 34	VGNC:14693	473860

Macaque	kelch like family member 34		696156

Mouse	kelch-like 34	MGI:2685234	245683

Rat	kelch-like family member 34	RGD:1560439	302703

Dog	kelch like family member 34	VGNC:42467	491769

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kelch like family member 34

Macaque	kelch like family member 34

Mouse	kelch-like 34

Rat	kelch-like family member 34

Dog	kelch like family member 34

Publication Statistics

PubMed Score 0.83

PubMed score by year

PubTator Score 0.53

PubTator score by year

Related Publications

Text Mined References (7)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Complete proteome

Kelch repeat

Reference proteome

Repeat