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Tdark
KLHL33
Kelch-like protein 33

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344581
  • ENSP00000341549
  • ENSG00000185271
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
tissue sample
0.62
protein domain
0.58
cell line
0.57
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.67   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.67   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999063801
p_ni:  0.000936199
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.997918161
p_ni:  0.002081839
Score:  0.669
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.994234284
p_ni:  0.005765716
Data Source:  BioPlex
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.993761172
p_ni:  0.006238828
Score:  0.288
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.991569398
p_ni:  0.008430602
Data Source:  BioPlex
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.988283555
p_ni:  0.011716445
Score:  0.183
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.987466197
p_ni:  0.012533803
Score:  0.216
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.945541317
p_ni:  0.054458683
Score:  0.666
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.90036813
p_ni:  0.09963187
Data Source:  BioPlex
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.876972441
p_ni:  0.123027559
Score:  0.343
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
1
1
73.6
metabolite measurement
1
1
1
65.6
aspartate aminotransferase measurement
2
1
1
6.8
62.1
1
1
0
1.6
27.3
serum alanine aminotransferase measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
73.6
metabolite measurement
1
65.6
aspartate aminotransferase measurement
1
6.8
62.1
0
1.6
27.3
serum alanine aminotransferase measurement
0
5.6
21.5
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 33
VGNC:12551
465199
Mouse
MGI:3644593
546611
Rat
RGD:2324282
100362676
Horse
kelch like family member 33
VGNC:51546
100072582
Cow
kelch like family member 33
VGNC:30659
100141057
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 33
Mouse
Rat
Horse
kelch like family member 33
Cow
kelch like family member 33
Publication Statistics
PubMed Score 0.67
PubMed score by year
PubTator Score 0.18
PubTator score by year
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Related Publications
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PMID
Year
Title