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Tbio
KLHL25
Kelch-like protein 25

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337975
  • ENSP00000336800
  • ENSG00000183655

Symbol
  • ENC2
  • ENC2
  • ENC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
small molecule perturbation
0.7
virus perturbation
0.68
transcription factor
0.66
transcription factor binding site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (308)
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999999985
p_ni:  1.4e-8
p_wrong:  1e-9
Data Source:  BioPlex
EMID1
Tbio
Novelty:  0.14161673
p_int:  0.999999775
p_ni:  2.24e-7
p_wrong:  1e-9
Score:  0.416
Data Source:  BioPlex,STRINGDB
ENC1
Tbio
Novelty:  0.01942998
p_int:  0.999999707
p_ni:  2.43e-7
p_wrong:  5e-8
Score:  0.855
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.99999919
p_ni:  8.1e-7
Score:  0.976
Data Source:  BioPlex,STRINGDB
PCGF2
Tbio
Novelty:  0.02148755
p_int:  0.999998215
p_ni:  0.000001785
Score:  0.163
Data Source:  BioPlex,STRINGDB
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.999157262
p_ni:  0.000238465
p_wrong:  0.000604274
Score:  0.173
Data Source:  BioPlex,STRINGDB
FBXL16
Tdark
Novelty:  0.96762375
Score:  0.94
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.939
Data Source:  STRINGDB
FBXL13
Tdark
Novelty:  0.33362589
Score:  0.936
Data Source:  STRINGDB
FBXL12
Tdark
Novelty:  0.30007519
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental genotype effect measurement
1
2
2
81.8
birth weight
2
2
3
81.8
eosinophil percentage of leukocytes
2
2
2
71
appendicular lean mass
1
1
1
66
mean corpuscular volume
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental genotype effect measurement
2
81.8
birth weight
3
81.8
eosinophil percentage of leukocytes
2
71
appendicular lean mass
1
66
mean corpuscular volume
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 25
VGNC:3541
453622
Mouse
MGI:2668031
207952
Rat
RGD:1310815
293023
Dog
kelch like family member 25
VGNC:42459
488725
Cow
kelch like family member 25
VGNC:30653
529905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 25
Mouse
Rat
Dog
kelch like family member 25
Cow
kelch like family member 25
Publication Statistics
PubMed Score 6.08
PubMed score by year
PubTator Score 0.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title