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Tbio
KLHL22
Kelch-like protein 22

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328879
  • ENSP00000331682
  • ENSG00000099910

Symbol
  • KELCHL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.86
kinase perturbation
0.76
small molecule perturbation
0.75
biological process
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (360)
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
p_int:  1
Score:  0.732
Data Source:  BioPlex,STRINGDB
SCARF2
Tbio
Novelty:  0.08833851
p_int:  1
Score:  0.653
Data Source:  BioPlex,STRINGDB
LYRM4
Tbio
Novelty:  0.03319832
p_int:  0.999999562
p_ni:  3.79e-7
p_wrong:  5.9e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
METTL15
Tdark
Family:  Enzyme
Novelty:  0.4575663
p_int:  0.999997517
p_ni:  0.000002483
Data Source:  BioPlex
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.999996264
p_ni:  0.000003386
p_wrong:  3.5e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.999956603
p_ni:  0.000043397
Score:  0.924
Data Source:  BioPlex,STRINGDB
SCAF8
Tbio
Novelty:  0.1650699
p_int:  0.999926768
p_ni:  0.000073232
Data Source:  BioPlex
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
p_int:  0.999717749
p_ni:  0.000282251
Data Source:  BioPlex
FMC1
Tbio
Novelty:  0.06702205
p_int:  0.999674091
p_ni:  0.000325393
p_wrong:  5.15e-7
Data Source:  BioPlex
MICU2
Tbio
Novelty:  0.04146208
p_int:  0.999617418
p_ni:  0.000382582
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
3
83.2
forced expiratory volume
1
1
1
46.1
mathematical ability
3
1
3
42.3
balding measurement
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
3
83.2
forced expiratory volume
1
46.1
mathematical ability
3
42.3
balding measurement
1
10
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 22
VGNC:5275
458666
Mouse
MGI:1337995
224023
Rat
RGD:1306288
303792
Dog
kelch like family member 22
VGNC:42457
486433
Horse
kelch like family member 22
VGNC:19468
100049928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 22
Mouse
Rat
Dog
kelch like family member 22
Horse
kelch like family member 22
Publication Statistics
PubMed Score 4.38
PubMed score by year
PubTator Score 2.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title