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Tbio
KLHL21
Kelch-like protein 21

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377658
  • ENSP00000366886
  • ENSG00000162413
  • ENST00000377663
  • ENSP00000366891

Symbol
  • KIAA0469
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
kinase perturbation
0.96
protein domain
0.92
transcription factor binding site profile
0.89
transcription factor
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (327)
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999999488
p_ni:  5.1e-7
p_wrong:  1e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
RCL1
Tbio
Family:  Enzyme
Novelty:  0.02116964
p_int:  0.999994962
p_ni:  0.000005037
p_wrong:  1e-9
Data Source:  BioPlex
KLHL28
Tdark
Novelty:  1.1777024
p_int:  0.99999365
p_ni:  0.000006106
p_wrong:  2.43e-7
Score:  0.549
Data Source:  BioPlex,STRINGDB
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.999987986
p_ni:  0.000012008
p_wrong:  6e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
ZBTB44
Tdark
Family:  TF
Novelty:  0.75195191
p_int:  0.999987326
p_ni:  0.000012674
Score:  0.232
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.999970366
p_ni:  0.000029633
Data Source:  BioPlex
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.999967292
p_ni:  0.000032706
p_wrong:  2e-9
Data Source:  BioPlex
TNNI2
Tbio
Novelty:  0.02772952
p_int:  0.999760359
p_ni:  0.000238169
p_wrong:  0.000001472
Score:  0.245
Data Source:  BioPlex,STRINGDB
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.999012719
p_ni:  0.000986557
p_wrong:  7.24e-7
Data Source:  BioPlex
NUMB
Tbio
Novelty:  0.00211228
p_int:  0.998302901
p_ni:  0.001472891
p_wrong:  0.000224209
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
87.6
FEV/FEC ratio
1
1
1
78.2
type 2 diabetes mellitus
2
2
2
74.2
comparative body size at age 10, self-reported
1
1
1
61.8
mean corpuscular volume
1
1
1
59.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
87.6
FEV/FEC ratio
1
78.2
type 2 diabetes mellitus
2
74.2
comparative body size at age 10, self-reported
1
61.8
mean corpuscular volume
1
59.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 21
VGNC:10697
457900
Macaque
kelch like family member 21 [Source:HGNC Symbol;Acc:HGNC:29041]
Mouse
MGI:1919288
242785
Rat
RGD:1305863
313743
Dog
kelch like family member 21
VGNC:42456
489634
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 21
Macaque
kelch like family member 21 [Source:HGNC Symbol;Acc:HGNC:29041]
Mouse
Rat
Dog
kelch like family member 21
Publication Statistics
PubMed Score 7.08
PubMed score by year
PubTator Score 1.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title