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Tbio
KLHL2
Kelch-like protein 2

Protein Summary
Description
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226725
  • ENSP00000226725
  • ENSG00000109466
  • ENST00000514860
  • ENSP00000424198
  • ENST00000538127
  • ENSP00000437526

Symbol
  • MAV
  • MAYVEN
  • ABP-KELCH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.81
kinase perturbation
0.76
transcription factor perturbation
0.74
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.94   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.94   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (394)
KLHL3
Tbio
Novelty:  0.04045086
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.999999994
p_ni:  6e-9
Score:  0.641
Data Source:  BioPlex,STRINGDB
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
KLHL17
Tdark
Novelty:  0.22103723
p_int:  0.999999981
p_ni:  8e-9
p_wrong:  1.2e-8
Score:  0.218
Data Source:  BioPlex,STRINGDB
TRIM47
Tbio
Novelty:  0.01631355
p_int:  0.999999965
p_ni:  5e-9
p_wrong:  3e-8
Data Source:  BioPlex
PIK3C2B
Tchem
Family:  Kinase
Novelty:  0.02410654
p_int:  0.999999871
p_ni:  1.28e-7
p_wrong:  1e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999999753
p_ni:  2.47e-7
Data Source:  BioPlex
WNK3
Tchem
Family:  Kinase
Novelty:  0.03382701
p_int:  0.999999744
p_ni:  2.56e-7
Score:  0.718
Data Source:  BioPlex,STRINGDB
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
p_int:  0.999999351
p_ni:  6.49e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
TRIM9
Tbio
Family:  Enzyme
Novelty:  0.06250762
p_int:  0.999999253
p_ni:  7.46e-7
p_wrong:  1e-9
Score:  0.913
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
66.2
self reported educational attainment
1
1
1
59
mathematical ability
1
1
1
48.5
cognitive function measurement
1
1
1
33.1
insulin measurement
1
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
66.2
self reported educational attainment
1
59
mathematical ability
1
48.5
cognitive function measurement
1
33.1
insulin measurement
2
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 2
VGNC:2983
461590
Macaque
kelch like family member 2
704790
Mouse
MGI:1924363
77113
Rat
RGD:1306388
290692
Dog
kelch like family member 2
VGNC:42454
475490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 2
Macaque
kelch like family member 2
Mouse
Rat
Dog
kelch like family member 2
Publication Statistics
PubMed Score 19.94
PubMed score by year
PubTator Score 32.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title