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Tdark
KLHL18
Kelch-like protein 18

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232766
  • ENSP00000232766
  • ENSG00000114648

Symbol
  • KIAA0795
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.93
protein domain
0.92
histone modification site profile
0.88
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.39   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.39   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999998933
p_ni:  0.000001067
Score:  0.718
Data Source:  BioPlex,STRINGDB
PCMT1
Tbio
Family:  Enzyme
Novelty:  0.01414946
p_int:  0.99960789
p_ni:  0.00039211
Data Source:  BioPlex
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.999485731
p_ni:  0.000514269
Score:  0.166
Data Source:  BioPlex,STRINGDB
FUBP3
Tbio
Novelty:  0.0393152
p_int:  0.999474833
p_ni:  0.000525128
p_wrong:  3.9e-8
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999411977
p_ni:  0.000588013
p_wrong:  1e-8
Data Source:  BioPlex
ATP6V1G1
Tbio
Family:  Enzyme
Novelty:  0.07710789
p_int:  0.998206889
p_ni:  0.001791809
p_wrong:  0.000001302
Score:  0.187
Data Source:  BioPlex,STRINGDB
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.997871834
p_ni:  0.002128166
Data Source:  BioPlex
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.996259191
p_ni:  0.003740809
Score:  0.364
Data Source:  BioPlex,STRINGDB
DCUN1D2
Tchem
Novelty:  1.02957984
p_int:  0.99168441
p_ni:  0.008007688
p_wrong:  0.000307903
Data Source:  BioPlex
LAD1
Tbio
Novelty:  0.03059679
p_int:  0.990506981
p_ni:  0.009255231
p_wrong:  0.000237788
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
88
sex hormone-binding globulin measurement
2
1
2
78.1
neutrophil percentage of leukocytes
1
1
1
68.8
alkaline phosphatase measurement
1
1
1
68.6
platelet count
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
88
sex hormone-binding globulin measurement
2
78.1
neutrophil percentage of leukocytes
1
68.8
alkaline phosphatase measurement
1
68.6
platelet count
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 18
VGNC:6351
741991
Macaque
kelch like family member 18
711943
Mouse
MGI:2143315
270201
Rat
RGD:1310570
316012
Dog
kelch like family member 18
VGNC:42453
484783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 18
Macaque
kelch like family member 18
Mouse
Rat
Dog
kelch like family member 18
Publication Statistics
PubMed Score 3.39
PubMed score by year
PubTator Score 0.42
PubTator score by year
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Related Publications
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PMID
Year
Title