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Tdark
KLHL17
Kelch-like protein 17

Protein Summary
Description
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338591
  • ENSP00000343930
  • ENSG00000187961
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.75
cellular component
0.6
tissue sample
0.6
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999981
p_ni:  8e-9
p_wrong:  1.2e-8
Score:  0.218
Data Source:  BioPlex,STRINGDB
PDZK1P1
Tdark
p_int:  0.999544558
p_ni:  0.000001519
p_wrong:  0.000453923
Data Source:  BioPlex
DCN
Tbio
Novelty:  0.00073027
p_int:  0.995539871
p_ni:  0.000002171
p_wrong:  0.004457958
Score:  0.485
Data Source:  BioPlex,STRINGDB
GRIK2
Tclin
Family:  IC
Novelty:  0.00293615
Score:  0.791
Data Source:  STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.707
Data Source:  STRINGDB
DSTYK
Tchem
Family:  Kinase
Novelty:  0.12049855
Score:  0.687
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.642
Data Source:  STRINGDB
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.627
Data Source:  STRINGDB
PLEKHN1
Tbio
Novelty:  0.33160373
Score:  0.624
Data Source:  STRINGDB
SAMD11
Tdark
Novelty:  0.32977476
Score:  0.586
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
59.6
apolipoprotein A 1 measurement
2
2
2
52
high density lipoprotein cholesterol measurement
2
2
2
47.4
alkaline phosphatase measurement
1
1
1
46.9
hip bone size
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
59.6
apolipoprotein A 1 measurement
2
52
high density lipoprotein cholesterol measurement
2
47.4
alkaline phosphatase measurement
1
46.9
hip bone size
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 17
VGNC:14033
100608762
Macaque
kelch like family member 17
699402
Mouse
MGI:2387630
231002
Rat
RGD:708444
246757
Dog
kelch like family member 17
VGNC:42452
489607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 17
Macaque
kelch like family member 17
Mouse
Rat
Dog
kelch like family member 17
Publication Statistics
PubMed Score 4.44
PubMed score by year
PubTator Score 1.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title