Protein Summary
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
- ENST00000338591
- ENSP00000343930
- ENSG00000187961
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
cell type or tissue | 0.75 | ||
cellular component | 0.6 | ||
tissue sample | 0.6 | ||
virus perturbation | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.44 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 18 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.44 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 18 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (34)
Nearest Tclin Targets
Pathways (1)
UniProt (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
UniProt | Protein modification; protein ubiquitination. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein modification; protein ubiquitination. | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (7)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.3 | 59.6 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 52 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 47.4 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 46.9 | |||||
hip bone size | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 59.6 | |||||
apolipoprotein A 1 measurement | 2 | 52 | |||||
high density lipoprotein cholesterol measurement | 2 | 47.4 | |||||
alkaline phosphatase measurement | 1 | 46.9 | |||||
hip bone size | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kelch like family member 17 | VGNC:14033 | 100608762 | |||||
Macaque | kelch like family member 17 | 699402 | ||||||
Mouse | MGI:2387630 | 231002 | ||||||
Rat | RGD:708444 | 246757 | ||||||
Dog | kelch like family member 17 | VGNC:42452 | 489607 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kelch like family member 17 | |||||
Macaque | kelch like family member 17 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kelch like family member 17 | |||||
Publication Statistics
PubMed Score 4.44
PubMed score by year
PubTator Score 1.43
PubTator score by year
Related Publications
Text Mined References (6)
Items per page:
0 of 0
PMID | Year | Title |
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