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Tbio
KLHL15
Kelch-like protein 15

Protein Summary
Description
Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354). This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328046
  • ENSP00000332791
  • ENSG00000174010

Symbol
  • KIAA1677
  • HEL-S-305
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.83
virus perturbation
0.79
transcription factor perturbation
0.68
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.55   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.55   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
ELP5
Tbio
Novelty:  0.07212185
p_int:  0.999579672
p_ni:  0.000012928
p_wrong:  0.0004074
Score:  0.795
Data Source:  BioPlex,STRINGDB
TOR1AIP1
Tbio
Novelty:  0.09110893
p_int:  0.999166029
p_ni:  0.000833971
Score:  0.163
Data Source:  BioPlex,STRINGDB
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
p_int:  0.998815913
p_ni:  0.001184083
p_wrong:  5e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
RNF34
Tbio
Family:  Enzyme
Novelty:  0.04365307
p_int:  0.997889296
p_ni:  0.002110704
Data Source:  BioPlex
CER1
Tbio
Novelty:  0.01834422
p_int:  0.997810553
p_ni:  0.002189447
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.997524105
p_ni:  0.002475895
Data Source:  BioPlex
ZNF511
Tdark
Novelty:  1.07235474
p_int:  0.996946707
p_ni:  0.003053293
Data Source:  BioPlex
C2orf68
Tdark
Novelty:  0.7947239
p_int:  0.995693639
p_ni:  0.004306361
Data Source:  BioPlex
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.9905543
p_ni:  0.0094457
Score:  0.683
Data Source:  BioPlex,STRINGDB
KISS1
Tbio
Novelty:  0.00096537
p_int:  0.98311583
p_ni:  0.01688417
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
1
12.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 15
VGNC:2749
473533
Mouse
MGI:1923400
236904
Rat
RGD:1563101
314111
Dog
kelch like family member 15
VGNC:42451
491777
Horse
kelch like family member 15
VGNC:19463
100052043
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 15
Mouse
Rat
Dog
kelch like family member 15
Horse
kelch like family member 15
Publication Statistics
PubMed Score 3.55
PubMed score by year
PubTator Score 2.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title