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Tbio
KLHL14
Kelch-like protein 14

Protein Summary
Description
The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358095
  • ENSP00000350808
  • ENSG00000197705
  • ENST00000359358
  • ENSP00000352314

Symbol
  • KIAA1384
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
trait
0.61
microRNA
0.58
tissue sample
0.58
tissue
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
KLHL28
Tdark
Novelty:  1.1777024
p_int:  0.999999965
p_ni:  1.3e-8
p_wrong:  2.3e-8
Score:  0.823
Data Source:  BioPlex,STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
p_int:  0.999999858
p_ni:  1.4e-7
p_wrong:  2e-9
Data Source:  BioPlex
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
p_int:  0.999995877
p_ni:  0.000004122
p_wrong:  2e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
KCTD21
Tbio
Novelty:  1.05252269
p_int:  0.999973539
p_ni:  0.00001625
p_wrong:  0.000010211
Score:  0.28
Data Source:  BioPlex,STRINGDB
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.999765149
p_ni:  0.000234851
Score:  0.55
Data Source:  BioPlex,STRINGDB
FBXL17
Tbio
Novelty:  0.16122137
p_int:  0.998933283
p_ni:  0.000737941
p_wrong:  0.000328776
Score:  0.697
Data Source:  BioPlex,STRINGDB
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
p_int:  0.996020846
p_ni:  0.003979154
Score:  0.346
Data Source:  BioPlex,STRINGDB
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.966520156
p_ni:  0.033479844
Score:  0.603
Data Source:  BioPlex,STRINGDB
TOR1A
Tbio
Novelty:  0.00056274
Score:  0.759
Data Source:  STRINGDB
SUSD6
Tbio
Novelty:  0.08836898
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 14
VGNC:5177
468517
Macaque
kelch like family member 14 [Source:HGNC Symbol;Acc:HGNC:29266]
Mouse
MGI:1921249
225266
Rat
RGD:1566178
364823
Dog
kelch like family member 14
VGNC:42450
490494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 14
Macaque
kelch like family member 14 [Source:HGNC Symbol;Acc:HGNC:29266]
Mouse
Rat
Dog
kelch like family member 14
Publication Statistics
PubMed Score 9.13
PubMed score by year
PubTator Score 1.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title