Tdark KLHL13 Kelch-like protein 13

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9P2N7
• B3KV78
• B3KWM7
• B7Z3S9
• B7Z5P2
• B7Z802
• D3DWH6
• Q6P2E3
• Q96QI7
• Q9UDN9

Gene Name

• KLHL13

Ensembl ID

• ENST00000262820
• ENSP00000262820
• ENSG00000003096
• ENST00000469946
• ENSP00000419803
• ENST00000540167
• ENSP00000441029
• ENST00000541812
• ENSP00000444450
• ENST00000545703
• ENSP00000440707

Symbol

• BKLHD2
• KIAA1309
• BKLHD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.8
virus perturbation	0.79
trait	0.75
cell type or tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.88   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.88   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (321)

Explore Interacting Targets

1 – 10 of 321

• See Interactions on String-DB

KLHL28

Tdark

Novelty:  1.1777024

p_int:  0.980013763

p_ni:  0.019986237

Score:  0.199

Data Source:  BioPlex,STRINGDB

KLHL9

Tdark

Novelty:  0.22434722

p_int:  0.955507154

p_ni:  0.044492846

Score:  0.953

Data Source:  BioPlex,STRINGDB

KLHL22

Tbio

Novelty:  0.24456252

p_int:  0.915413431

p_ni:  0.084586569

Score:  0.955

Data Source:  BioPlex,STRINGDB

PPP1R16B

Tbio

Family:  Enzyme

Novelty:  0.08773047

p_int:  0.827611618

p_ni:  0.172388382

Score:  0.345

Data Source:  BioPlex,STRINGDB

CUL3

Tbio

Novelty:  0.0028737

Score:  0.995

Data Source:  STRINGDB

AURKB

Tchem

Family:  Kinase

Novelty:  0.00100972

Score:  0.988

Data Source:  STRINGDB

COPS4

Tbio

Novelty:  0.04672417

Score:  0.955

Data Source:  STRINGDB

COPS2

Tbio

Novelty:  0.03509351

Score:  0.954

Data Source:  STRINGDB

UBE2D1

Tbio

Novelty:  0.00865867

Score:  0.947

Data Source:  STRINGDB

KLHL21

Tbio

Novelty:  0.20694121

Score:  0.946

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (7)

KEGG (1)

PathwayCommons (1)

UniProt (1)

Adaptive Immune System (R-HSA-1280218)

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1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Immune System	2246 targets	R-HSA-168256
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (3)

Processes (5)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
Cul3-RING ubiquitin ligase complex	Inferred from Direct Assay (IDA)	UniProtKB
midbody	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytosol	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell division
Complete proteome
Kelch repeat
Mitosis
Polymorphism
Reference proteome
Repeat
Ubl conjugation pathway

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	kelch like family member 13		710546
Mouse	kelch-like 13	MGI:1914705	67455
Rat	kelch-like family member 13	RGD:1559646	313445
Dog	kelch like family member 13	VGNC:42449	492088
Horse	kelch like family member 13	VGNC:19462	100053772

Species	Name	OMA	EggNOG	Inparanoid
Macaque	kelch like family member 13
Mouse	kelch-like 13
Rat	kelch-like family member 13
Dog	kelch like family member 13
Horse	kelch like family member 13

Publication Statistics

PubMed Score 3.88

PubMed score by year

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PubTator Score 0.95

PubTator score by year

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Related Publications

Text Mined References (12)

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10

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PMID	Year	Title