Protein Summary
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
- ENST00000262820
- ENSP00000262820
- ENSG00000003096
- ENST00000469946
- ENSP00000419803
- ENST00000540167
- ENSP00000441029
- ENST00000541812
- ENSP00000444450
- ENST00000545703
- ENSP00000440707
- BKLHD2
- KIAA1309
- BKLHD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.92 | ||
transcription factor perturbation | 0.8 | ||
virus perturbation | 0.79 | ||
trait | 0.75 | ||
cell type or tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.88 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 126 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.88 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 126 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (321)
KLHL28
Novelty: 1.1777024
p_int: 0.980013763
p_ni: 0.019986237
Score: 0.199
Data Source: BioPlex,STRINGDB
KLHL9
Novelty: 0.22434722
p_int: 0.955507154
p_ni: 0.044492846
Score: 0.953
Data Source: BioPlex,STRINGDB
KLHL22
Novelty: 0.24456252
p_int: 0.915413431
p_ni: 0.084586569
Score: 0.955
Data Source: BioPlex,STRINGDB
PPP1R16B
Family: Enzyme
Novelty: 0.08773047
p_int: 0.827611618
p_ni: 0.172388382
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (7)
KEGG (1)
PathwayCommons (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | kelch like family member 13 | 710546 | ||||||
Mouse | MGI:1914705 | 67455 | ||||||
Rat | RGD:1559646 | 313445 | ||||||
Dog | kelch like family member 13 | VGNC:42449 | 492088 | |||||
Horse | kelch like family member 13 | VGNC:19462 | 100053772 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | kelch like family member 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kelch like family member 13 | |||||
Horse | kelch like family member 13 | |||||
Publication Statistics
PubMed Score 3.88
PubMed score by year
PubTator Score 0.95
PubTator score by year
Related Publications
Text Mined References (12)
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