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Tbio
KLHL11
Kelch-like protein 11

Protein Summary
Description
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319121
  • ENSP00000314608
  • ENSG00000178502
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.68
tissue sample
0.59
histone modification site profile
0.53
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (391)
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.999993234
p_ni:  0.000006766
Score:  0.16
Data Source:  BioPlex,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.999992611
p_ni:  0.000007389
Data Source:  BioPlex
ENDOU
Tbio
Family:  Enzyme
Novelty:  0.01074988
p_int:  0.999986599
p_ni:  0.000008136
p_wrong:  0.000005265
Data Source:  BioPlex
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.999983764
p_ni:  0.000016234
p_wrong:  2e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
CRABP2
Tchem
Novelty:  0.0050363
p_int:  0.999977575
p_ni:  0.000022417
p_wrong:  8e-9
Data Source:  BioPlex
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999966079
p_ni:  0.000033912
p_wrong:  9e-9
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.99994791
p_ni:  0.00005209
Data Source:  BioPlex
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
p_int:  0.99993833
p_ni:  0.000061669
p_wrong:  1e-9
Data Source:  BioPlex
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999925119
p_ni:  0.000074871
p_wrong:  1e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
ANXA3
Tbio
Novelty:  0.00615077
p_int:  0.999907761
p_ni:  0.000083375
p_wrong:  0.000008864
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
5
7
96.5
reticulocyte measurement
3
3
4
94.7
heel bone mineral density
3
2
4
78.7
balding measurement
1
1
1
64.4
eosinophil count
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
96.5
reticulocyte measurement
4
94.7
heel bone mineral density
4
78.7
balding measurement
1
64.4
eosinophil count
2
48.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 11
VGNC:9349
104001120
Macaque
kelch like family member 11
708393
Mouse
MGI:2388648
217194
Rat
RGD:1306673
287706
Dog
kelch like family member 11
VGNC:42447
480520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 11
Macaque
kelch like family member 11
Mouse
Rat
Dog
kelch like family member 11
Publication Statistics
PubMed Score 15.23
PubMed score by year
PubTator Score 1.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title