Tbio KLHL1 Kelch-like protein 1

Protein Summary

Description

May play a role in organizing the actin cytoskeleton of the brain cells. The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 [PubMed 10888605]).[supplied by OMIM, Feb 2010]

Uniprot Accession IDs

• Q9NR64
• A8K5X0
• Q5VZ64
• Q9H4X4
• Q9NR65
• Q9P238

Gene Name

• KLHL1

Ensembl ID

• ENST00000377844
• ENSP00000367075
• ENSG00000150361

Symbol

• KIAA1490
• MRP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
protein domain	0.85
gene perturbation	0.84
cell type or tissue	0.71
disease	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.39   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 265   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.39   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0