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Tbio
KLHL1
Kelch-like protein 1

Protein Summary
Description
May play a role in organizing the actin cytoskeleton of the brain cells. The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 [PubMed 10888605]).[supplied by OMIM, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377844
  • ENSP00000367075
  • ENSG00000150361

Symbol
  • KIAA1490
  • MRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
protein domain
0.85
gene perturbation
0.84
cell type or tissue
0.71
disease
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.999995197
p_ni:  0.000004802
Data Source:  BioPlex
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.999986714
p_ni:  0.000013286
Data Source:  BioPlex
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.999962503
p_ni:  0.000037497
Data Source:  BioPlex
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
p_int:  0.986562872
p_ni:  0.013437128
Score:  0.167
Data Source:  BioPlex,STRINGDB
RNASEH2A
Tbio
Family:  Enzyme
Novelty:  0.00478657
p_int:  0.830861214
p_ni:  0.16913864
p_wrong:  1.47e-7
Data Source:  BioPlex
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.820236158
p_ni:  0.179763842
Data Source:  BioPlex
DNAJC12
Tbio
Novelty:  0.05214775
p_int:  0.751164951
p_ni:  0.245796543
p_wrong:  0.003038506
Data Source:  BioPlex
SOCS6
Tbio
Novelty:  0.00993375
Score:  0.749
Data Source:  STRINGDB
MEA1
Tbio
Novelty:  0.04292367
Score:  0.742
Data Source:  STRINGDB
NAA16
Tbio
Family:  Enzyme
Novelty:  0.23261397
Score:  0.697
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
1
1
0
1.1
49.5
stenosing tenosynovitis
1
1
0
1.7
42.3
environmental tobacco smoke exposure measurement
1
1
0
1.6
15.8
age at onset
1
1
0
1.6
15.8
childhood onset asthma
1
1
0
1.6
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
0
1.1
49.5
stenosing tenosynovitis
0
1.7
42.3
environmental tobacco smoke exposure measurement
0
1.6
15.8
age at onset
0
1.6
15.8
childhood onset asthma
0
1.6
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 1
VGNC:5302
452594
Macaque
kelch like family member 1
708779
Mouse
MGI:2136335
93688
Dog
kelch like family member 1
VGNC:42445
485487
Cow
kelch like family member 1
VGNC:53821
614976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 1
Macaque
kelch like family member 1
Mouse
Dog
kelch like family member 1
Cow
kelch like family member 1
Publication Statistics
PubMed Score 20.44
PubMed score by year
PubTator Score 6.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title