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Tbio
KLHDC8B
Kelch domain-containing protein 8B

Protein Summary
Description
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010). This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332780
  • ENSP00000327468
  • ENSG00000185909

Symbol
  • CHL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
tissue sample
0.64
histone modification site profile
0.55
transcription factor
0.5
disease
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999997858
p_ni:  0.000001842
p_wrong:  3e-7
Score:  0.315
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.997816509
p_ni:  0.000003897
p_wrong:  0.002179594
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.997816509
p_ni:  0.000003897
p_wrong:  0.002179594
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.970609646
p_ni:  0.000001724
p_wrong:  0.02938863
Score:  0.222
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.967112829
p_ni:  5.67e-7
p_wrong:  0.032886604
Score:  0.173
Data Source:  BioPlex,STRINGDB
KBTBD12
Tdark
Novelty:  3.42794501
Score:  0.792
Data Source:  STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
Score:  0.761
Data Source:  STRINGDB
TMEM204
Tdark
Novelty:  0.21947862
Score:  0.746
Data Source:  STRINGDB
CCDC36
Tbio
Novelty:  0.17724141
Score:  0.741
Data Source:  STRINGDB
KCNG3
Tclin
Family:  IC
Novelty:  0.19740057
Score:  0.733
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
3
1
82.3
body fat distribution
2
1
4
70.5
urate measurement
1
1
1
68.3
chronotype measurement
1
1
0
1.1
68
wellbeing measurement
4
3
4
60.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
82.3
body fat distribution
4
70.5
urate measurement
1
68.3
chronotype measurement
0
1.1
68
wellbeing measurement
4
60.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 8B
VGNC:11425
470818
Macaque
kelch domain containing 8B
707348
Mouse
MGI:1925517
78267
Rat
RGD:1359445
306589
Dog
kelch domain containing 8B
VGNC:42444
484771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 8B
Macaque
kelch domain containing 8B
Mouse
Rat
Dog
kelch domain containing 8B
Publication Statistics
PubMed Score 7.33
PubMed score by year
PubTator Score 8.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title