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Tdark
KLHDC8A
Kelch domain-containing protein 8A

Protein Summary
Description
This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367155
  • ENSP00000356123
  • ENSG00000162873
  • ENST00000367156
  • ENSP00000356124
  • ENST00000539253
  • ENSP00000442229
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
PubMedID
0.51
gene perturbation
0.48
cell line
0.44
transcription factor binding site profile
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.996492284
p_ni:  0.003507716
Data Source:  BioPlex
LONP1
Tbio
Family:  Enzyme
Novelty:  0.00334137
p_int:  0.995814537
p_ni:  0.004185463
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.99396231
p_ni:  0.00603769
Score:  0.665
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.99311677
p_ni:  0.00688323
Score:  0.33
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.992208102
p_ni:  0.007791898
Score:  0.313
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.991605426
p_ni:  0.008394574
Score:  0.177
Data Source:  BioPlex,STRINGDB
PDCL
Tbio
Novelty:  0.00317454
p_int:  0.990918649
p_ni:  0.009081351
p_wrong:  1e-9
Score:  0.6
Data Source:  BioPlex,STRINGDB
TXNDC9
Tbio
Novelty:  0.00309772
p_int:  0.982700571
p_ni:  0.017299429
Score:  0.686
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.982191175
p_ni:  0.017808825
Score:  0.67
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.97707968
p_ni:  0.02292032
Score:  0.622
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
7
7
99.6
platelet count
3
4
3
2.8
96.9
reticulocyte measurement
3
4
4
96.7
reticulocyte count
4
2
4
93.5
mean reticulocyte volume
1
1
1
84.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
99.6
platelet count
3
2.8
96.9
reticulocyte measurement
4
96.7
reticulocyte count
4
93.5
mean reticulocyte volume
1
84.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 8A
VGNC:1289
469653
Macaque
kelch domain containing 8A
698312
Mouse
MGI:2442630
213417
Rat
RGD:1305132
305096
Dog
kelch domain containing 8A
VGNC:42443
488571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 8A
Macaque
kelch domain containing 8A
Mouse
Rat
Dog
kelch domain containing 8A
Publication Statistics
PubMed Score 1.07
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title