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Tdark
KLHDC4
Kelch domain-containing protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270583
  • ENSP00000270583
  • ENSG00000104731
  • ENST00000347925
  • ENSP00000325717
  • ENST00000353170
  • ENSP00000262530
  • ENST00000567298
  • ENSP00000457570
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.84
cell type or tissue
0.78
cellular component
0.75
cell line
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
CROT
Tbio
Family:  Enzyme
Novelty:  0.01860427
p_int:  0.998419702
p_ni:  0.00000291
p_wrong:  0.001577389
Score:  0.485
Data Source:  BioPlex,STRINGDB
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
Score:  0.808
Data Source:  STRINGDB
BOP1
Tbio
Novelty:  0.03512044
Score:  0.734
Data Source:  STRINGDB
ARMC6
Tdark
Novelty:  0.58706267
Score:  0.728
Data Source:  STRINGDB
SDAD1
Tdark
Novelty:  0.2574139
Score:  0.683
Data Source:  STRINGDB
BMS1
Tbio
Novelty:  0.0349992
Score:  0.652
Data Source:  STRINGDB
PUM3
Tbio
Novelty:  0.02344206
Score:  0.64
Data Source:  STRINGDB
MAK16
Tdark
Novelty:  0.07717917
Score:  0.639
Data Source:  STRINGDB
DMAC1
Tbio
Novelty:  1.16519301
Score:  0.609
Data Source:  STRINGDB
BRIX1
Tbio
Novelty:  0.16561444
Score:  0.608
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
86.3
mean corpuscular volume
1
1
1
85.6
mean corpuscular hemoglobin concentration
1
1
1
84.9
blood metabolite measurement
1
1
1
77.3
platelet count
1
1
1
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
86.3
mean corpuscular volume
1
85.6
mean corpuscular hemoglobin concentration
1
84.9
blood metabolite measurement
1
77.3
platelet count
1
71.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 4
VGNC:13725
742286
Macaque
kelch domain containing 4
695768
Mouse
MGI:2384569
234825
Dog
kelch domain containing 4
VGNC:49812
489668
Horse
kelch domain containing 4
VGNC:49395
100070617
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 4
Macaque
kelch domain containing 4
Mouse
Dog
kelch domain containing 4
Horse
kelch domain containing 4
Publication Statistics
PubMed Score 1.60
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title