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Tbio
KLHDC2
Kelch domain-containing protein 2

Protein Summary
Description
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298307
  • ENSP00000298307
  • ENSG00000165516
  • ENST00000555443
  • ENSP00000450944
  • ENST00000555739
  • ENSP00000450539

Symbol
  • HCA33
  • LCP
  • HCLP1
  • HCLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
virus perturbation
0.98
disease perturbation
0.83
transcription factor binding site profile
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0