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Tdark
KLHDC10
Kelch domain-containing protein 10

Protein Summary
Description
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335420
  • ENSP00000334140
  • ENSG00000128607

Symbol
  • KIAA0265
  • slim
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.88
transcription factor binding site profile
0.86
kinase perturbation
0.76
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.999993026
p_ni:  0.000006973
p_wrong:  1e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
p_int:  0.999990057
p_ni:  0.000009788
p_wrong:  1.55e-7
Score:  0.532
Data Source:  BioPlex,STRINGDB
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999985242
p_ni:  0.000002824
p_wrong:  0.000011934
Score:  0.59
Data Source:  BioPlex,STRINGDB
KITLG
Tbio
Novelty:  0.00036337
p_int:  0.999962722
p_ni:  0.00003727
p_wrong:  8e-9
Score:  0.455
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999622342
p_ni:  0.000028997
p_wrong:  0.000348661
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.999218853
p_ni:  0.000626229
p_wrong:  0.000154918
Data Source:  BioPlex
MKLN1
Tbio
Novelty:  0.05014385
Score:  0.722
Data Source:  STRINGDB
KLHDC7A
Tdark
Novelty:  1.08722777
Score:  0.636
Data Source:  STRINGDB
BSDC1
Tdark
Novelty:  1.591335
Score:  0.591
Data Source:  STRINGDB
ZC3HC1
Tbio
Novelty:  0.089692
Score:  0.578
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
88.7
platelet crit
2
2
2
84.7
9
1
5
1.1
76.5
myeloid white cell count
1
1
1
72.6
sex hormone-binding globulin measurement
4
1
4
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
88.7
platelet crit
2
84.7
5
1.1
76.5
myeloid white cell count
1
72.6
sex hormone-binding globulin measurement
4
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 10
VGNC:14032
463723
Macaque
kelch domain containing 10
702290
Mouse
MGI:1924038
76788
Rat
RGD:1309792
312199
Dog
kelch domain containing 10
VGNC:42440
475195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 10
Macaque
kelch domain containing 10
Mouse
Rat
Dog
kelch domain containing 10
Publication Statistics
PubMed Score 2.14
PubMed score by year
PubTator Score 9.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title