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Tchem
KLF5
Krueppel-like factor 5

Protein Summary
Description
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377687
  • ENSP00000366915
  • ENSG00000102554
  • ENST00000539231
  • ENSP00000440407

Symbol
  • BTEB2
  • CKLF
  • IKLF
  • CKLF
  • IKLF
  • BTEB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
transcription factor binding site profile
0.91
hub protein
0.9
biological process
0.87
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.11   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.11   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (101)
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999878953
p_ni:  0.000121047
Data Source:  BioPlex
IVNS1ABP
Tbio
Novelty:  0.04220812
p_int:  0.991866366
p_ni:  0.004330862
p_wrong:  0.003802772
Data Source:  BioPlex
PUS1
Tbio
Family:  Enzyme
Novelty:  0.01923618
p_int:  0.987477042
p_ni:  0.012522958
Data Source:  BioPlex
CEBPB
Tbio
Family:  TF
Novelty:  0.00068108
Score:  0.979
Data Source:  STRINGDB
CEBPA
Tbio
Family:  TF
Novelty:  0.00056459
Score:  0.976
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.962
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.948
Data Source:  STRINGDB
CEBPD
Tbio
Family:  TF
Novelty:  0.00121121
Score:  0.939
Data Source:  STRINGDB
EBF1
Tbio
Family:  TF
Novelty:  0.00445405
Score:  0.928
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.782
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of granulopoiesis
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of granulopoiesis
Transcriptional regulation of white adipocyte differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
59.4
1
1
1
53.7
monocyte count
1
1
1
49.5
2
1
0
1.1
42.3
response to low sodium diet
1
1
0
2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
59.4
1
53.7
monocyte count
1
49.5
0
1.1
42.3
response to low sodium diet
0
2
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Kruppel like factor 5
694320
Mouse
MGI:1338056
12224
Rat
RGD:621446
84410
Dog
Kruppel like factor 5
VGNC:42437
612788
Horse
Kruppel like factor 5
VGNC:19446
100052058
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Kruppel like factor 5
Mouse
Rat
Dog
Kruppel like factor 5
Horse
Kruppel like factor 5
Publication Statistics
PubMed Score 346.11
PubMed score by year
PubTator Score 138.34
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title