KLF4
Krueppel-like factor 4
Protein Summary
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor ...more
- ENST00000374672
- ENSP00000363804
- ENSG00000136826
- EZF
- GKLF
- EZF
- GKLF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
gene perturbation | 1 | ||
PubMedID | 1 | ||
molecular function | 0.99 | ||
virus perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1398.89 (req: < 5)
Gene RIFs: 335 (req: <= 3)
Antibodies: 864 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1398.89 (req: >= 5)
Gene RIFs: 335 (req: > 3)
Antibodies: 864 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 65
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (288)
Nearest Tclin Targets (3)
Upstream (3)
Pathways (23)
Reactome (11)
KEGG (1)
PathwayCommons (2)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of cell cycle genes | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of cell cycle genes | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (71)
Functions (14)
Components (6)
Processes (51)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.4 | 12.3 | |||||
2 | 1 | 0 | 1.1 | 7.9 | |||||
glomerular filtration rate | 1 | 1 | 1 | 3.6 | |||||
creatinine measurement | 1 | 1 | 1 | 3.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 12.3 | |||||
0 | 1.1 | 7.9 | |||||
glomerular filtration rate | 1 | 3.6 | |||||
creatinine measurement | 1 | 3.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Kruppel like factor 4 | VGNC:13903 | 464640 | |||||
Macaque | Kruppel like factor 4 | 711169 | ||||||
Mouse | MGI:1342287 | 16600 | ||||||
Rat | RGD:621445 | 114505 | ||||||
Dog | Kruppel like factor 4 | 481657 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Kruppel like factor 4 | |||||
Macaque | Kruppel like factor 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Kruppel like factor 4 | |||||
Publication Statistics
PubMed Score 1398.89
PubMed score by year
PubTator Score 610.00
PubTator score by year
Related Publications
Text Mined References (355)
GeneRif Annotations (335)
Items per page:
0 of 0
PMID | Year | Title |
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