Tbio KLF4 Krueppel-like factor 4

Protein Summary

Description

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• O43474
• B2R8S4
• B3KT79
• L0R3I6
• L0R4N5
• P78338
• Q5T3J8
• Q5T3J9
• Q8N717
• Q9UNP3

Gene Name

• KLF4

Ensembl ID

• ENST00000374672
• ENSP00000363804
• ENSG00000136826

Symbol

• EZF
• GKLF
• EZF
• GKLF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	1
PubMedID	1
molecular function	0.99
virus perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Krueppel-like Factor 4

Protein / Transcription Factor / Transcription Cofactor / Krueppel-like Factor 4

Protein / Nucleic Acid Binding / Dna Binding Protein / Krueppel-like Factor 4

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Krueppel-like Factor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1562.46   (req: < 5)

Gene RIFs: 466   (req: <= 3)

Antibodies: 864   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1562.46   (req: >= 5)

Gene RIFs: 466   (req: > 3)

Antibodies: 864   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0