Tbio KLF12 Krueppel-like factor 12

Protein Summary

Description

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y4X4
• A8K5T2
• L0R3J4
• Q5VZM7
• Q9UHZ0

Gene Name

• KLF12

Ensembl ID

• ENST00000377669
• ENSP00000366897
• ENSG00000118922

Symbol

• AP2REP
• AP2REP
• AP-2rep
• HSPC122

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
virus perturbation	0.95
trait	0.93
kinase perturbation	0.84
molecular function	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Krueppel-like Factor 12

Protein / Transcription Factor / Transcription Cofactor / Krueppel-like Factor 12

Protein / Nucleic Acid Binding / Dna Binding Protein / Krueppel-like Factor 12

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Krueppel-like Factor 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.59   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.59   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0