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Tbio
KIZ
Centrosomal protein kizuna

Protein Summary
Description
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000616848
  • ENSP00000480612
  • ENSG00000088970
  • ENST00000619189
  • ENSP00000479542
  • ENST00000620891
  • ENSP00000478019

Symbol
  • C20orf19
  • NCRNA00153
  • PLK1S1
  • RP69
  • HT013
  • Kizuna
  • PLK1S1
  • C20orf19
  • NCRNA00153
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.81
kinase perturbation
0.71
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
SCLT1
Tbio
Novelty:  0.10969171
p_int:  0.99999996
p_ni:  1e-9
p_wrong:  4e-8
Score:  0.936
Data Source:  BioPlex,STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.99999788
p_ni:  0.000002117
p_wrong:  3e-9
Score:  0.669
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999993852
p_ni:  0.000003403
p_wrong:  0.000002744
Score:  0.516
Data Source:  BioPlex,STRINGDB
DPYSL3
Tbio
Family:  Enzyme
Novelty:  0.01284077
p_int:  0.999898859
p_ni:  0.000101141
Score:  0.188
Data Source:  BioPlex,STRINGDB
BMX
Tchem
Family:  Kinase
Novelty:  0.00383533
p_int:  0.999472383
p_ni:  0.000527602
p_wrong:  1.5e-8
Score:  0.209
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.941
Data Source:  STRINGDB
CEP72
Tbio
Novelty:  0.06830459
Score:  0.712
Data Source:  STRINGDB
VSIG10L
Tdark
Novelty:  0.8815667
Score:  0.672
Data Source:  STRINGDB
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
Score:  0.67
Data Source:  STRINGDB
ZSCAN26
Tdark
Novelty:  0.21423827
Score:  0.658
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
4
90.6
body height
2
2
2
83.6
red blood cell distribution width
1
1
1
57.3
3
3
2
5.7
48.5
BMI-adjusted hip circumference
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
90.6
body height
2
83.6
red blood cell distribution width
1
57.3
2
5.7
48.5
BMI-adjusted hip circumference
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2684960
228730
Cow
kizuna centrosomal protein
VGNC:30620
513688
Chicken
kizuna centrosomal protein
CGNC:6354
421237
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
kizuna centrosomal protein
Chicken
kizuna centrosomal protein
Publication Statistics
PubMed Score 14.07
PubMed score by year
PubTator Score 7.17
PubTator score by year
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Related Publications
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PMID
Year
Title