Protein Summary
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand ...more
- ENST00000228280
- ENSP00000228280
- ENSG00000049130
- ENST00000347404
- ENSP00000054216
- ENST00000644744
- ENSP00000495951
- MGF
- SCF
- SF
- MGF
- SCF
- SLF
- DCUA
- FPH2
- FPHH
- KL-1
- Kitl
- SHEP7
- DFNA69
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
biological process | 0.97 | ||
biological term | 0.97 | ||
gene perturbation | 0.91 | ||
PubMedID | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2712.48 (req: < 5)
Gene RIFs: 171 (req: <= 3)
Antibodies: 828 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2712.48 (req: >= 5)
Gene RIFs: 171 (req: > 3)
Antibodies: 828 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (302)
KLHDC10
Novelty: 0.40978227
p_int: 0.999962722
p_ni: 0.00003727
p_wrong: 8e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
ATP8B2
Family: Transporter
Novelty: 0.09269537
p_int: 0.985642839
p_ni: 0.014357161
Score: 0.534
Data Source: BioPlex,STRINGDB
SLC22A18
Family: Transporter
Novelty: 0.0189809
p_int: 0.864467356
p_ni: 0.135388639
p_wrong: 0.000144005
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Downstream (18)
1 – 5 of 18
Pathways (91)
Reactome (20)
KEGG (8)
PathwayCommons (11)
WikiPathways (52)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | FLT3 Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
FLT3 Signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (5)
Components (8)
Processes (21)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
6 | 4 | 0 | 2.4 | 97 | |||||
hair color | 1 | 2 | 0 | 1.1 | 88 | ||||
2 | 1 | 0 | 2 | 87.6 | |||||
myeloid white cell count | 2 | 2 | 2 | 81.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 2.4 | 97 | |||||
hair color | 0 | 1.1 | 88 | ||||
0 | 2 | 87.6 | |||||
myeloid white cell count | 2 | 81.4 | |||||
red blood cell density measurement | 1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | KIT ligand | VGNC:5442 | 452114 | |||||
Macaque | KIT ligand | 574254 | ||||||
Mouse | MGI:96974 | 17311 | ||||||
Rat | RGD:3086 | 60427 | ||||||
Dog | KIT ligand | VGNC:42423 | 403507 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | KIT ligand | |||||
Macaque | KIT ligand | |||||
Mouse | ||||||
Rat | ||||||
Dog | KIT ligand | |||||
Publication Statistics
PubMed Score 2712.48
PubMed score by year
PubTator Score 2278.54
PubTator score by year
Related Publications
Text Mined References (221)
GeneRif Annotations (171)
Items per page:
0 of 0
PMID | Year | Title |
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