Tbio KITLG Kit ligand

Protein Summary

Description

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21583
• A0AV09
• A8K2Q4
• B7ZLM4
• Q16487
• Q68DZ2
• Q7M4N8
• Q9UQK7

Gene Name

• KITLG

Ensembl ID

• ENST00000228280
• ENSP00000228280
• ENSG00000049130
• ENST00000347404
• ENSP00000054216
• ENST00000644744
• ENSP00000495951

Symbol

• MGF
• SCF
• SF
• MGF
• SCF
• SLF
• DCUA
• FPH2
• FPHH
• KL-1
• Kitl
• SHEP7
• DFNA69

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
biological process	0.97
biological term	0.97
gene perturbation	0.91
PubMedID	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2712.48   (req: < 5)

Gene RIFs: 171   (req: <= 3)

Antibodies: 828   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2712.48   (req: >= 5)

Gene RIFs: 171   (req: > 3)

Antibodies: 828   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (302)

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1 – 10 of 302

• See Interactions on String-DB

KLHDC10

Tdark

Novelty:  0.40978227

p_int:  0.999962722

p_ni:  0.00003727

p_wrong:  8e-9

Score:  0.455

Data Source:  BioPlex,STRINGDB

ATP8B2

Tbio

Family:  Transporter

Novelty:  0.09269537

p_int:  0.985642839

p_ni:  0.014357161

Score:  0.534

Data Source:  BioPlex,STRINGDB

SLC22A18

Tbio

Family:  Transporter

Novelty:  0.0189809

p_int:  0.864467356

p_ni:  0.135388639

p_wrong:  0.000144005

Score:  0.2

Data Source:  BioPlex,STRINGDB

KIT

Tclin

Family:  Kinase

Novelty:  0.00011237

Score:  0.999

Data Source:  Reactome,STRINGDB

EPO

Tbio

Novelty:  0.00013701

Score:  0.984

Data Source:  STRINGDB

EPOR

Tclin

Novelty:  0.00134388

Score:  0.97

Data Source:  STRINGDB

PDGFRB

Tclin

Family:  Kinase

Novelty:  0.00074896

Score:  0.967

Data Source:  STRINGDB

STAT3

Tchem

Family:  TF

Novelty:  0.00011808

Score:  0.966

Data Source:  Reactome,STRINGDB

MATK

Tbio

Family:  Kinase

Novelty:  0.00068411

Score:  0.957

Data Source:  STRINGDB

FLT3

Tclin

Family:  Kinase

Novelty:  0.0003477

Score:  0.948

Data Source:  STRINGDB

Nearest Tclin Targets (18)

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Downstream (18)

1 – 5 of 18

IGF1R

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  5

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Ras signaling pathway

4: MAPK signaling pathway

5: Pathways in cancer

FLT1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  4

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Ras signaling pathway

4: MAPK signaling pathway

PDGFRA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  6

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Ras signaling pathway

4: MAPK signaling pathway

more:  2 more common pathways

KIT

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  8

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Ras signaling pathway

4: MAPK signaling pathway

more:  4 more common pathways

FGFR3

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  5

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Ras signaling pathway

4: MAPK signaling pathway

5: Pathways in cancer

Pathways (91)

Reactome (20)

KEGG (8)

PathwayCommons (11)

WikiPathways (52)

Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	FLT3 Signaling	264 targets	R-HSA-9607240

Name	Explore in Pharos	Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
FLT3 Signaling	264 targets	R-HSA-9607240

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (34)

Functions (5)

Components (8)

Processes (21)

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1 – 5 of 5

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome
Ras guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
stem cell factor receptor binding	Traceable Author Statement (TAS)	ProtInc
cytokine activity	Inferred from Electronic Annotation (IEA)	Ensembl
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (22)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testicular carcinoma	EFO_0005088	6	4	0	2.4	97
hair color	EFO_0003924	1	2	0	1.1	88
Testicular Germ Cell Tumor	EFO_1000566	2	1	0	2	87.6
myeloid white cell count	EFO_0007988	2	2	2		81.4
red blood cell density measurement	EFO_0007978	1	1	1		39.6

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testicular carcinoma	EFO_0005088	0	2.4	97
hair color	EFO_0003924	0	1.1	88
Testicular Germ Cell Tumor	EFO_1000566	0	2	87.6
myeloid white cell count	EFO_0007988	2		81.4
red blood cell density measurement	EFO_0007978	1		39.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Deafness
Direct protein sequencing

GWAS Trait Find Similar Targets

No Header	No Header
chronotype measurement
disease recurrence
erythrocyte count
erythrocyte measurement
granulocyte count
hair color
leukocyte count
lymphocyte percentage of leukocytes
mean corpuscular hemoglobin concentration
mean corpuscular volume

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	KIT ligand	VGNC:5442	452114
Macaque	KIT ligand		574254
Mouse	kit ligand	MGI:96974	17311
Rat	KIT ligand	RGD:3086	60427
Dog	KIT ligand	VGNC:42423	403507

Species	Name	OMA	EggNOG	Inparanoid
Chimp	KIT ligand
Macaque	KIT ligand
Mouse	kit ligand
Rat	KIT ligand
Dog	KIT ligand

Publication Statistics

PubMed Score 2712.48

PubMed score by year

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PubTator Score 2278.54

PubTator score by year

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Related Publications

Text Mined References (221)

GeneRif Annotations (171)

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PMID	Year	Title