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Tbio
KIRREL2
Kin of IRRE-like protein 2

Protein Summary
Description
May regulate basal insulin secretion. This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360202
  • ENSP00000353331
  • ENSG00000126259

Symbol
  • NEPH3
  • NLG1
  • NEPH3
  • FILTRIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.72
histone modification site profile
0.68
cellular component
0.59
PubMedID
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.999634532
p_ni:  0.000365467
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.967340375
p_ni:  0.032659625
Score:  0.177
Data Source:  BioPlex,STRINGDB
CPS1
Tclin
Family:  Enzyme
Novelty:  0.00917469
p_int:  0.965352265
p_ni:  0.034647735
Score:  0.209
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.876353372
p_ni:  0.123646628
Data Source:  BioPlex
MANBA
Tchem
Family:  Enzyme
Novelty:  0.00961026
p_int:  0.870505399
p_ni:  0.129494601
Score:  0.187
Data Source:  BioPlex,STRINGDB
NPHS1
Tbio
Novelty:  0.00104742
Score:  0.953
Data Source:  Reactome,STRINGDB
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.804
Data Source:  STRINGDB
NPHS2
Tbio
Novelty:  0.00212981
Score:  0.8
Data Source:  STRINGDB
ITK
Tclin
Family:  Kinase
Novelty:  0.00054195
Score:  0.728
Data Source:  STRINGDB
EPHA5
Tchem
Family:  Kinase
Novelty:  0.01143252
Score:  0.678
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Nephrin family interactions
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Nephrin family interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
78.5
creatinine measurement
1
1
1
66.8
thrombomodulin measurement
1
1
1
64
glomerular filtration rate
1
1
1
62.8
vitamin D measurement
2
1
2
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
78.5
creatinine measurement
1
66.8
thrombomodulin measurement
1
64
glomerular filtration rate
1
62.8
vitamin D measurement
2
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kirre like nephrin family adhesion molecule 2
455966
Macaque
kirre like nephrin family adhesion molecule 2
711175
Mouse
MGI:2442334
243911
Rat
RGD:1308456
100359836
Dog
kirre like nephrin family adhesion molecule 2
VGNC:42419
484570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kirre like nephrin family adhesion molecule 2
Macaque
kirre like nephrin family adhesion molecule 2
Mouse
Rat
Dog
kirre like nephrin family adhesion molecule 2
Publication Statistics
PubMed Score 38.54
PubMed score by year
PubTator Score 19.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title