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Tdark
KIR3DS1
Killer cell immunoglobulin-like receptor 3DS1

Protein Summary
Description
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613279
  • ENSP00000484010
  • ENSG00000276534
  • ENST00000614217
  • ENSP00000481772
  • ENSG00000275434
  • ENST00000615275
  • ENSP00000481993
  • ENSG00000276498
  • ENST00000616075
  • ENSP00000477733
  • ENSG00000275037
  • ENST00000616388
  • ENSP00000480199
  • ENSG00000274465
  • ENST00000616583
  • ENSP00000483460
  • ENSG00000275608
  • ENST00000619911
  • ENSP00000477859
  • ENSG00000274283

Symbol
  • NKAT10
  • KIR-G1
  • NKAT10
  • CD158E2
  • NKAT-10
  • KIR-123FM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
cell type or tissue
0.97
disease
0.95
microRNA
0.76
biological term
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
KIR3DL1
Tbio
Novelty:  0.00308245
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  5e-9
Data Source:  BioPlex
SERPINB7
Tbio
Novelty:  0.01685387
p_int:  0.999961105
p_ni:  0.000038895
Data Source:  BioPlex
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.999928771
p_ni:  0.000071229
Data Source:  BioPlex
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.996865533
p_ni:  0.003134467
Data Source:  BioPlex
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.99214552
p_ni:  0.00785448
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.989406088
p_ni:  0.010593911
p_wrong:  1e-9
Data Source:  BioPlex
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.988769185
p_ni:  0.001425486
p_wrong:  0.009805328
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.987477421
p_ni:  0.012522579
Data Source:  BioPlex
CALML5
Tbio
Novelty:  0.03240679
p_int:  0.980522369
p_ni:  0.019477631
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.971522973
p_ni:  0.028477024
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
DAP12 interactions (R-HSA-2172127)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DAP12 interactions
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
Items per page:
1 – 5 of 35
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
Items per page:
1 – 5 of 35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 78.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title