Tdark KIR2DS4 Killer cell immunoglobulin-like receptor 2DS4

Protein Summary

Description

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43632
• Q6H2G7

Gene Name

• KIR2DS4

Ensembl ID

• ENST00000611311
• ENSP00000484123
• ENSG00000276885
• ENST00000612783
• ENSP00000481753
• ENSG00000274957
• ENST00000613654
• ENSP00000483112
• ENSG00000276634
• ENST00000614639
• ENSP00000481319
• ENSG00000275731
• ENST00000617469
• ENSP00000477744
• ENSG00000276395
• ENST00000617825
• ENSP00000483274
• ENSG00000275353
• ENST00000619771
• ENSP00000478241
• ENSG00000274947
• ENST00000620669
• ENSP00000480062
• ENSG00000274406
• ENST00000621436
• ENSP00000479843
• ENSG00000276154
• ENST00000638566
• ENSP00000492248
• ENSG00000284264
• ENST00000640817
• ENSP00000491676
• ENSG00000283870
• ENST00000640941
• ENSP00000492546
• ENSG00000283882
• ENST00000642862
• ENSP00000494622
• ENST00000644051
• ENSP00000494670
• ENST00000644154
• ENSP00000495680

Symbol

• CD158I
• KKA3
• NKAT8
• KKA3
• KIR1D
• NKAT8
• CD158I
• KIR412
• NKAT-8
• KIR-2DS4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.79
cell type or tissue	0.73
phenotype	0.65
disease	0.54
cell line	0.51

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Killer Cell Immunoglobulin-like Receptor 2ds4

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Killer Cell Immunoglobulin-like Receptor 2ds4

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Killer Cell Immunoglobulin-like Receptor 2ds4

Protein / ... / Protease Inhibitor / Killer Cell Immunoglobulin-like Receptor 2ds4

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Killer Cell Immunoglobulin-like Receptor 2ds4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0