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Tdark
KIR2DS2
Killer cell immunoglobulin-like receptor 2DS2

Protein Summary
Description
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610441
  • ENSP00000484281
  • ENSG00000277885
  • ENST00000611495
  • ENSP00000484082
  • ENSG00000276425
  • ENST00000612182
  • ENSP00000478509
  • ENSG00000274438
  • ENST00000613378
  • ENSP00000482725
  • ENSG00000274518
  • ENST00000614231
  • ENSP00000482770
  • ENSG00000275253
  • ENST00000614727
  • ENSP00000483792
  • ENSG00000276139
  • ENST00000616472
  • ENSP00000482637
  • ENSG00000275452
  • ENST00000616541
  • ENSP00000484771
  • ENSG00000278300
  • ENST00000617284
  • ENSP00000478014
  • ENST00000617984
  • ENSP00000477892
  • ENSG00000275737
  • ENST00000618364
  • ENSP00000483804
  • ENSG00000275735
  • ENST00000619473
  • ENSP00000484400
  • ENSG00000276258
  • ENST00000622127
  • ENSP00000481307
  • ENSG00000278152

Symbol
  • CD158J
  • NKAT5
  • NKAT5
  • cl-49
  • CD158J
  • CD158b
  • NKAT-5
  • 183ActI
  • KIR-2DS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.99
phenotype
0.99
disease
0.94
cell type or tissue
0.93
microRNA
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
KIR2DS1
Tdark
p_int:  0.999999963
p_wrong:  3.7e-8
Data Source:  BioPlex
KIR2DS5
Tdark
p_int:  0.999999949
p_wrong:  5.1e-8
Data Source:  BioPlex
KIR3DL1
Tbio
Novelty:  0.00308245
p_int:  0.999999948
p_ni:  8e-9
p_wrong:  4.4e-8
Data Source:  BioPlex
MUC7
Tbio
Novelty:  0.00750654
p_int:  0.999895093
p_ni:  0.000038554
p_wrong:  0.000066353
Data Source:  BioPlex
BPIFA2
Tbio
Novelty:  0.01533858
p_int:  0.999810461
p_ni:  0.00017369
p_wrong:  0.00001585
Data Source:  BioPlex
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999806941
p_ni:  0.000184903
p_wrong:  0.000008156
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.999544728
p_ni:  0.000455264
p_wrong:  8e-9
Data Source:  BioPlex
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.998915497
p_ni:  0.000985841
p_wrong:  0.000098661
Data Source:  BioPlex
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.998761132
p_ni:  0.001238868
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.997066067
p_ni:  0.001135889
p_wrong:  0.001798044
Data Source:  BioPlex
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
DAP12 interactions
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 71.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title