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Tbio
KIR2DL1
Killer cell immunoglobulin-like receptor 2DL1

Protein Summary
Description
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and inst ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291633
  • ENSP00000291633
  • ENSG00000125498
  • ENST00000611611
  • ENSP00000478232
  • ENSG00000278738
  • ENST00000615920
  • ENSP00000482120
  • ENSG00000273794
  • ENST00000617376
  • ENSP00000484559
  • ENSG00000278821
  • ENST00000618563
  • ENSP00000484361
  • ENSG00000276625
  • ENST00000620449
  • ENSP00000478263
  • ENSG00000277833
  • ENST00000622463
  • ENSP00000479363
  • ENSG00000278495

Symbol
  • CD158A
  • NKAT1
  • NKAT
  • NKAT1
  • p58.1
  • CD158A
  • KIR221
  • NKAT-1
  • KIR-K64
  • KIR2DL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
cell type or tissue
0.93
disease
0.88
cell line
0.63
microRNA
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.71   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.71   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
KIR2DL2
Tdark
p_int:  0.999999996
p_wrong:  4e-9
Data Source:  BioPlex
KIR2DS3
Tdark
p_int:  0.999999993
p_wrong:  7e-9
Data Source:  BioPlex
KIR3DL1
Tbio
Novelty:  0.00308245
p_int:  0.999999979
p_ni:  1.7e-8
p_wrong:  3e-9
Score:  0.864
Data Source:  BioPlex,STRINGDB
FAM114A2
Tdark
Novelty:  0.40545319
p_int:  0.999999972
p_ni:  2.8e-8
Data Source:  BioPlex
RHBDF2
Tbio
Family:  Enzyme
Novelty:  0.02487334
p_int:  0.999995596
p_ni:  0.000004404
Data Source:  BioPlex
FLVCR1
Tbio
Novelty:  0.02110276
p_int:  0.999885941
p_ni:  0.000114059
Data Source:  BioPlex
PLCH1
Tbio
Family:  Enzyme
Novelty:  0.11128204
p_int:  0.999605689
p_ni:  0.000392744
p_wrong:  0.000001567
Data Source:  BioPlex
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.999396942
p_ni:  0.000603058
Data Source:  BioPlex
STX6
Tbio
Novelty:  0.01494028
p_int:  0.999203973
p_ni:  0.000676236
p_wrong:  0.000119791
Data Source:  BioPlex
GOSR1
Tbio
Novelty:  0.03139481
p_int:  0.999131105
p_ni:  0.000867019
p_wrong:  0.000001877
Data Source:  BioPlex
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
monocyte percentage of leukocytes
1
2
2
44
monocyte percentage of leukocytes
1
2
2
44
high density lipoprotein cholesterol measurement
1
1
1
34.9
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
48.5
lymphocyte count
2
48.5
monocyte percentage of leukocytes
2
44
monocyte percentage of leukocytes
2
44
high density lipoprotein cholesterol measurement
1
34.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 229.71
PubMed score by year
PubTator Score 112.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title