You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KIFC3
Kinesin-like protein KIFC3

Protein Summary
Description
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379655
  • ENSP00000368976
  • ENSG00000140859
  • ENST00000421376
  • ENSP00000396399
  • ENST00000445690
  • ENSP00000401696
  • ENST00000465878
  • ENSP00000454659
  • ENST00000541240
  • ENSP00000442008
  • ENST00000562903
  • ENSP00000456239
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.88
transcription factor binding site profile
0.83
cellular component
0.81
transcription factor
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.28   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.28   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999995912
p_ni:  3.97e-7
p_wrong:  0.000003691
Score:  0.224
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.99997741
p_ni:  2.7e-8
p_wrong:  0.000022563
Score:  0.632
Data Source:  BioPlex,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.947
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.944
Data Source:  STRINGDB
PLEKHA7
Tbio
Novelty:  0.05239328
Score:  0.933
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.93
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.926
Data Source:  STRINGDB
CAMSAP3
Tbio
Novelty:  0.04216784
Score:  0.91
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.882
Data Source:  STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.878
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Protein folding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member C3
VGNC:5830
454124
Macaque
kinesin family member C3
705951
Mouse
MGI:109202
16582
Rat
RGD:1307693
307644
Dog
kinesin family member C3
VGNC:42416
487259
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member C3
Macaque
kinesin family member C3
Mouse
Rat
Dog
kinesin family member C3
Publication Statistics
PubMed Score 14.28
PubMed score by year
PubTator Score 10.21
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title