You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KIFC1
Kinesin-like protein KIFC1

Protein Summary
Description
Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374523
  • ENSP00000363647
  • ENSG00000204197
  • ENST00000428849
  • ENSP00000393963
  • ENSG00000237649
  • ENST00000448818
  • ENSP00000407885
  • ENSG00000233450

Symbol
  • HSET
  • KNSL2
  • HSET
  • KNSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
molecular function
0.98
interacting protein
0.92
gene perturbation
0.77
PubMedID
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.53   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.53   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (278)
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999999982
p_ni:  1.4e-8
p_wrong:  4e-9
Score:  0.304
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999999836
p_ni:  1.35e-7
p_wrong:  2.9e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999839801
p_ni:  0.000160031
p_wrong:  1.68e-7
Data Source:  BioPlex
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.9997408
p_ni:  0.0002592
Score:  0.211
Data Source:  BioPlex,STRINGDB
KIF2C
Tbio
Novelty:  0.00498643
Score:  0.993
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.992
Data Source:  STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.987
Data Source:  STRINGDB
KIF18B
Tbio
Novelty:  0.06496349
Score:  0.986
Data Source:  STRINGDB
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
Score:  0.975
Data Source:  STRINGDB
KIF15
Tchem
Novelty:  0.01328603
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
3
2
0
1.1
56.6
3
2
0
1.1
56.6
1
2
0
1.1
55.2
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
63.4
body mass index
1
63.4
0
1.1
56.6
0
1.1
56.6
0
1.1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member C1
VGNC:11102
462615
Macaque
kinesin family member C1
717800
Mouse
MGI:2137414
16580
Mouse
MGI:109596
100502766
Rat
RGD:1359118
294286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member C1
Macaque
kinesin family member C1
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 110.53
PubMed score by year
PubTator Score 60.83
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title