Tbio KIFAP3 Kinesin-associated protein 3

Protein Summary

Description

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q92845
• B1AKU4
• B1AKU5
• B2RDL1
• B7Z8A3
• F5H591
• Q8NHU7
• Q9H416
• KAP-3

Gene Name

• KIFAP3

Ensembl ID

• ENST00000361580
• ENSP00000354560
• ENSG00000075945
• ENST00000367765
• ENSP00000356739
• ENST00000367767
• ENSP00000356741
• ENST00000538366
• ENSP00000444622

Symbol

• KIF3AP
• SMAP
• FLA3
• KAP3
• SMAP
• KAP-1
• KAP-3
• Smg-GDS
• dJ190I16.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.86
virus perturbation	0.85
histone modification site profile	0.79
tissue sample	0.68
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-associated Protein 3

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-associated Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.86   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.86   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0