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Tbio
KIF6
Kinesin-like protein KIF6

Protein Summary
Description
This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229913
  • ENSP00000229913
  • ENSG00000164627
  • ENST00000287152
  • ENSP00000287152

Symbol
  • C6orf102
  • C6orf102
  • dJ137F1.4
  • dJ188D3.1
  • dJ1043E3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.75
phenotype
0.74
tissue
0.65
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.64   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.64   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
SNX16
Tbio
Novelty:  0.13364491
p_int:  0.999999451
p_ni:  4.1e-8
p_wrong:  5.09e-7
Score:  0.466
Data Source:  BioPlex,STRINGDB
HEATR5A
Tdark
Novelty:  4.84461801
p_int:  0.999998635
p_ni:  0.000001223
p_wrong:  1.42e-7
Score:  0.547
Data Source:  BioPlex,STRINGDB
FEZ2
Tbio
Novelty:  0.1716508
p_int:  0.999755085
p_ni:  0.000244815
p_wrong:  1e-7
Score:  0.572
Data Source:  BioPlex,STRINGDB
MLLT10
Tbio
Family:  Epigenetic
Novelty:  0.00590548
p_int:  0.985212856
p_ni:  0.000073925
p_wrong:  0.014713219
Score:  0.295
Data Source:  BioPlex,STRINGDB
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
p_int:  0.901470495
p_ni:  0.098529505
Score:  0.209
Data Source:  BioPlex,STRINGDB
KIFC2
Tbio
Novelty:  0.10989267
Score:  0.947
Data Source:  STRINGDB
KIFC1
Tchem
Novelty:  0.00982095
Score:  0.943
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.943
Data Source:  STRINGDB
KIF25
Tbio
Novelty:  0.17030283
Score:  0.942
Data Source:  STRINGDB
KIF2C
Tbio
Novelty:  0.00498643
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.1
69.8
optic disc size measurement
1
1
1
59
body height
1
1
1
39.6
cup-to-disc ratio measurement
1
1
1
36.9
1
1
0
1.4
26.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
69.8
optic disc size measurement
1
59
body height
1
39.6
cup-to-disc ratio measurement
1
36.9
0
1.4
26.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 6
VGNC:3262
462668
Macaque
kinesin family member 6
719593
Mouse
MGI:1098238
319991
Rat
RGD:621070
171291
Dog
kinesin family member 6
VGNC:42410
481782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 6
Macaque
kinesin family member 6
Mouse
Rat
Dog
kinesin family member 6
Publication Statistics
PubMed Score 48.64
PubMed score by year
PubTator Score 44.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title