Tbio KIF5B Kinesin-1 heavy chain

Protein Summary

Description

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).

Uniprot Accession IDs

• P33176
• A0AVB2
• Q5VZ85

Gene Name

• KIF5B

Ensembl ID

• ENST00000302418
• ENSP00000307078
• ENSG00000170759

Symbol

• KNS
• KNS1
• KNS
• KINH
• KNS1
• UKHC
• HEL-S-61

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
hub protein	0.94
disease perturbation	0.9
transcription factor perturbation	0.8
microRNA	0.78

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-1 Heavy Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-1 Heavy Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.76   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 443   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.76   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 443   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0