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Tbio
KIF4A
Chromosome-associated kinesin KIF4A

Protein Summary
Description
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374403
  • ENSP00000363524
  • ENSG00000090889

Symbol
  • KIF4
  • KIF4
  • KIF4G1
  • MRX100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.91
transcription factor perturbation
0.91
histone modification site profile
0.87
gene perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.45   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.45   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (343)
SPATA6L
Tdark
Novelty:  3.37083829
p_int:  0.999999997
p_ni:  3e-9
Score:  0.68
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999989874
p_ni:  0.000002886
p_wrong:  0.00000724
Data Source:  BioPlex
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.988842621
p_ni:  0.000429523
p_wrong:  0.010727856
Data Source:  BioPlex
KIF11
Tchem
Novelty:  0.00170673
Score:  0.996
Data Source:  STRINGDB
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
Score:  0.996
Data Source:  STRINGDB
KIF23
Tbio
Novelty:  0.00719651
Score:  0.995
Data Source:  STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.995
Data Source:  STRINGDB
CENPE
Tchem
Novelty:  0.00458125
Score:  0.993
Data Source:  STRINGDB
KIF2C
Tbio
Novelty:  0.00498643
Score:  0.991
Data Source:  STRINGDB
KIF15
Tchem
Novelty:  0.01328603
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Developmental Biology
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
COPI-dependent Golgi-to-ER retrograde traffic
Developmental Biology
Factors involved in megakaryocyte development and platelet production
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
78.4
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 4A
VGNC:12446
747952
Dog
kinesin family member 4A
491941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 4A
Dog
kinesin family member 4A
Publication Statistics
PubMed Score 134.45
PubMed score by year
PubTator Score 47.04
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title