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Tbio
KIF3B
Kinesin-like protein KIF3B

Protein Summary
Description
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375712
  • ENSP00000364864
  • ENSG00000101350

Symbol
  • KIAA0359
  • FLA8
  • HH0048
  • KLP-11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.91
histone modification site profile
0.88
virus perturbation
0.88
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.83   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.83   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (211)
KIFAP3
Tbio
Novelty:  0.01902437
p_int:  0.999999988
p_ni:  2e-9
p_wrong:  1.1e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999999982
p_ni:  5e-9
p_wrong:  1.3e-8
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.999918658
p_ni:  0.000081333
p_wrong:  9e-9
Score:  0.6
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.989979397
p_ni:  0.002914762
p_wrong:  0.007105841
Score:  0.557
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
Score:  0.988
Data Source:  Reactome,STRINGDB
IFT52
Tbio
Novelty:  0.04183122
Score:  0.978
Data Source:  STRINGDB
IFT88
Tbio
Novelty:  0.00727114
Score:  0.973
Data Source:  STRINGDB
DYNC2H1
Tbio
Novelty:  0.01306616
Score:  0.97
Data Source:  STRINGDB
IFT57
Tbio
Novelty:  0.03373199
Score:  0.97
Data Source:  STRINGDB
IFT172
Tbio
Novelty:  0.01114005
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cilium Assembly
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Cilium Assembly
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
3
78.7
blood protein measurement
1
1
1
77.1
granulocyte percentage of myeloid white cells
1
1
1
53.6
suntan
1
1
1
42.8
smoking cessation
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
78.7
blood protein measurement
1
77.1
granulocyte percentage of myeloid white cells
1
53.6
suntan
1
42.8
smoking cessation
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 3B
VGNC:6180
458166
Macaque
kinesin family member 3B
711883
Mouse
MGI:107688
16569
Rat
RGD:1306815
296284
Dog
kinesin family member 3B
VGNC:42405
485830
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 3B
Macaque
kinesin family member 3B
Mouse
Rat
Dog
kinesin family member 3B
Publication Statistics
PubMed Score 58.83
PubMed score by year
PubTator Score 19.91
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title