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Tbio
KIF3A
Kinesin-like protein KIF3A

Protein Summary
Description
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378746
  • ENSP00000368020
  • ENSG00000131437

Symbol
  • KIF3
  • FLA10
  • KLP-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
microRNA
0.81
kinase perturbation
0.76
cell line
0.65
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.89   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.89   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (319)
KIFAP3
Tbio
Novelty:  0.01902437
p_int:  1
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
KIF3B
Tbio
Novelty:  0.01877656
p_int:  0.999999982
p_ni:  5e-9
p_wrong:  1.3e-8
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.99999991
p_ni:  9e-8
Score:  0.588
Data Source:  BioPlex,STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
p_int:  0.999999876
p_ni:  6.3e-8
p_wrong:  6.2e-8
Data Source:  BioPlex
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.999999601
p_ni:  3.99e-7
Data Source:  BioPlex
KIF3C
Tbio
Novelty:  0.0512445
p_int:  0.999998872
p_ni:  0.000001123
p_wrong:  5e-9
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
p_int:  0.999967572
p_ni:  0.000032428
p_wrong:  1e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.999874923
p_ni:  0.000125077
Data Source:  BioPlex
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
p_int:  0.999717473
p_ni:  0.000282527
Score:  0.366
Data Source:  BioPlex,STRINGDB
ATG9B
Tbio
p_int:  0.999706789
p_ni:  0.000024908
p_wrong:  0.000268303
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (111)
Activation of SMO (R-HSA-5635838)

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Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cilium Assembly
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Activation of SMO
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Cilium Assembly
Factors involved in megakaryocyte development and platelet production
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
10
1
1.1
97.3
eosinophil count
2
3
3
95.1
5
6
0
1.1
94.3
5
5
2
1.1
92.7
eosinophil percentage of leukocytes
1
2
2
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
97.3
eosinophil count
3
95.1
0
1.1
94.3
2
1.1
92.7
eosinophil percentage of leukocytes
2
92.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 3A
VGNC:4063
450168
Macaque
kinesin family member 3A
574270
Mouse
MGI:107689
16568
Rat
RGD:621536
84392
Dog
kinesin family member 3A
VGNC:42404
474675
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 3A
Macaque
kinesin family member 3A
Mouse
Rat
Dog
kinesin family member 3A
Publication Statistics
PubMed Score 183.89
PubMed score by year
PubTator Score 61.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title