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Tbio
KIF2C
Kinesin-like protein KIF2C

Protein Summary
Description
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372217
  • ENSP00000361291
  • ENSG00000142945
  • ENST00000372224
  • ENSP00000361298

Symbol
  • KNSL6
  • MCAK
  • CT139
  • KNSL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein complex
0.99
interacting protein
0.98
transcription factor perturbation
0.98
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.05   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.05   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (454)
PAPLN
Tbio
Novelty:  0.06871524
p_int:  0.999992946
p_ni:  0.000007054
Score:  0.189
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.99998825
p_ni:  0.00001175
Data Source:  BioPlex
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999890439
p_ni:  0.000109561
Data Source:  BioPlex
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.995393609
p_ni:  0.000224098
p_wrong:  0.004382293
Score:  0.914
Data Source:  BioPlex,Reactome,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.987219576
p_ni:  0.012780422
p_wrong:  2e-9
Data Source:  BioPlex
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.986135897
p_ni:  0.013864099
p_wrong:  4e-9
Data Source:  BioPlex
RBMX2
Tbio
Novelty:  0.08867468
p_int:  0.979960496
p_ni:  0.020023689
p_wrong:  0.000015816
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.978898503
p_ni:  0.019620305
p_wrong:  0.001481192
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.978837414
p_ni:  0.021017878
p_wrong:  0.000144708
Score:  0.311
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.969563316
p_ni:  0.029782677
p_wrong:  0.000654007
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (183)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
0
7
54.4
red blood cell distribution width
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
0
7
54.4
red blood cell distribution width
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 2C
VGNC:1288
456548
Macaque
kinesin family member 2C
705381
Mouse
MGI:1921054
73804
Rat
RGD:620239
171529
Dog
kinesin family member 2C
VGNC:42403
475382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 2C
Macaque
kinesin family member 2C
Mouse
Rat
Dog
kinesin family member 2C
Publication Statistics
PubMed Score 224.05
PubMed score by year
PubTator Score 112.96
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title