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Tbio
KIF2B
Kinesin-like protein KIF2B

Protein Summary
Description
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268919
  • ENSP00000268919
  • ENSG00000141200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
gene perturbation
0.9
cell line
0.7
cellular component
0.66
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.21   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.21   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (276)
SIKE1
Tbio
Novelty:  0.14549184
p_int:  0.999999976
p_ni:  2.3e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
DAPK3
Tchem
Family:  Kinase
Novelty:  0.01551494
p_int:  0.999999727
p_ni:  2.67e-7
p_wrong:  6e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
CEP170B
Tdark
Novelty:  0.30498676
p_int:  0.999984513
p_ni:  0.000015292
p_wrong:  1.95e-7
Score:  0.689
Data Source:  BioPlex,STRINGDB
SAV1
Tbio
Novelty:  0.00962335
p_int:  0.999982527
p_ni:  0.000017473
Data Source:  BioPlex
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999980753
p_ni:  0.000019246
Data Source:  BioPlex
SPC25
Tbio
Novelty:  0.26354244
p_int:  0.999891337
p_ni:  0.000108663
Score:  0.912
Data Source:  BioPlex,STRINGDB
TXLNG
Tbio
Novelty:  0.08274423
p_int:  0.999802308
p_ni:  0.000197691
Score:  0.158
Data Source:  BioPlex,STRINGDB
KLC4
Tdark
Novelty:  0.32552746
p_int:  0.999642345
p_ni:  0.000357655
Score:  0.915
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.999461424
p_ni:  0.000538576
Score:  0.7
Data Source:  BioPlex,STRINGDB
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
p_int:  0.999402989
p_ni:  0.000597011
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
1
1
26.1
body height
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
26.1
body height
1
0.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 2B
VGNC:12348
468409
Macaque
kinesin family member 2B
705683
Mouse
MGI:1920720
73470
Rat
RGD:1359248
287624
Dog
kinesin family member 2B [Source:HGNC Symbol;Acc:HGNC:29443]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 2B
Macaque
kinesin family member 2B
Mouse
Rat
Dog
kinesin family member 2B [Source:HGNC Symbol;Acc:HGNC:29443]
Publication Statistics
PubMed Score 8.21
PubMed score by year
PubTator Score 7.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title