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Tbio
KIF22
Kinesin-like protein KIF22

Protein Summary
Description
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000160827
  • ENSP00000160827
  • ENSG00000079616
  • ENST00000400751
  • ENSP00000383562
  • ENST00000561482
  • ENSP00000454957

Symbol
  • KID
  • KNSL4
  • KID
  • OBP
  • KNSL4
  • OBP-1
  • OBP-2
  • SEMDJL2
  • A-328A3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.97
kinase perturbation
0.93
protein domain
0.92
protein complex
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.21   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.21   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (280)
TBC1D15
Tbio
Novelty:  0.11296513
p_int:  0.999999995
p_ni:  5e-9
Score:  0.254
Data Source:  BioPlex,STRINGDB
CNPY2
Tbio
Novelty:  0.090889
p_int:  0.999999535
p_ni:  4.65e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.999993043
p_ni:  0.000006955
p_wrong:  2e-9
Data Source:  BioPlex
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999983132
p_ni:  0.00001576
p_wrong:  0.000001108
Score:  0.266
Data Source:  BioPlex,STRINGDB
KPNA4
Tbio
Novelty:  0.01326511
p_int:  0.998359089
p_ni:  0.001640911
Score:  0.219
Data Source:  BioPlex,STRINGDB
KPNA3
Tbio
Novelty:  0.02173035
p_int:  0.990691816
p_ni:  0.009308184
Score:  0.229
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.935323596
p_ni:  0.064676404
Data Source:  BioPlex
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.83261923
p_ni:  0.16738077
Data Source:  BioPlex
KIF4A
Tbio
Novelty:  0.00888393
Score:  0.982
Data Source:  Reactome,STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
72.9
alcohol consumption measurement
3
1
3
64
bitter alcoholic beverage consumption measurement
1
1
1
48.5
body fat distribution
1
1
1
15.8
BMI-adjusted waist circumference
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
72.9
alcohol consumption measurement
3
64
bitter alcoholic beverage consumption measurement
1
48.5
body fat distribution
1
15.8
BMI-adjusted waist circumference
1
3.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 22
VGNC:5829
454026
Macaque
kinesin family member 22
706401
Mouse
MGI:109233
110033
Rat
RGD:1311886
293502
Dog
kinesin family member 22
VGNC:42398
489938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 22
Macaque
kinesin family member 22
Mouse
Rat
Dog
kinesin family member 22
Publication Statistics
PubMed Score 110.21
PubMed score by year
PubTator Score 73.17
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title