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Tbio
KIF1A
Kinesin-like protein KIF1A

Protein Summary
Description
Motor for anterograde axonal transport of synaptic vesicle precursors. The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404283
  • ENSP00000384231
  • ENSG00000130294
  • ENST00000498729
  • ENSP00000438388
  • ENST00000649096
  • ENSP00000497030
  • ENST00000650053
  • ENSP00000497824

Symbol
  • ATSV
  • C2orf20
  • ATSV
  • MRD9
  • HSN2C
  • SPG30
  • UNC104
  • C2orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
disease perturbation
0.79
interacting protein
0.73
PubMedID
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.59   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.59   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0