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Tbio
KIF18B
Kinesin-like protein KIF18B

Protein Summary
Description
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000590129
  • ENSP00000465501
  • ENSG00000186185
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.88
cellular component
0.8
co-expressed gene
0.79
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.3   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.3   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.999999746
p_ni:  2.53e-7
p_wrong:  2e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.999999038
p_ni:  9.62e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999995642
p_ni:  0.000004358
Data Source:  BioPlex
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.99998215
p_ni:  0.00001785
Score:  0.625
Data Source:  BioPlex,STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.999191021
p_ni:  0.000808979
Score:  0.154
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.998276452
p_ni:  0.001723548
Score:  0.173
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.997411172
p_ni:  0.002570671
p_wrong:  0.000018158
Data Source:  BioPlex
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.996119866
p_ni:  0.003880121
p_wrong:  1.4e-8
Data Source:  BioPlex
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.992334137
p_ni:  0.007665817
p_wrong:  4.6e-8
Data Source:  BioPlex
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.988690442
p_ni:  0.008691879
p_wrong:  0.002617679
Score:  0.925
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
84.5
self reported educational attainment
1
2
2
63.7
hip bone size
1
1
1
17.1
chronotype measurement
1
1
1
6.4
cognitive function measurement
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
84.5
self reported educational attainment
2
63.7
hip bone size
1
17.1
chronotype measurement
1
6.4
cognitive function measurement
1
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2446979
70218
Rat
RGD:1310360
303575
Dog
kinesin family member 18B
VGNC:42388
490932
Horse
kinesin family member 18B
VGNC:19399
100050343
Cow
kinesin family member 18B
VGNC:30588
511170
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
kinesin family member 18B
Horse
kinesin family member 18B
Cow
kinesin family member 18B
Publication Statistics
PubMed Score 24.30
PubMed score by year
PubTator Score 7.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title