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Tchem
KIF15
Kinesin-like protein KIF15

Protein Summary
Description
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326047
  • ENSP00000324020
  • ENSG00000163808
  • ENST00000627272
  • ENSP00000486004
  • ENSG00000280610

Symbol
  • KLP2
  • KNSL7
  • KLP2
  • HKLP2
  • KNSL7
  • NY-BR-62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.92
transcription factor binding site profile
0.85
transcription factor perturbation
0.8
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.3   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.3   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (312)
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.99999999
p_wrong:  9e-9
Score:  0.331
Data Source:  BioPlex,STRINGDB
PHYHIP
Tdark
Family:  Enzyme
Novelty:  0.25773185
p_int:  0.999956642
p_ni:  0.000043358
Score:  0.516
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.997325093
p_ni:  0.002646131
p_wrong:  0.000028777
Score:  0.161
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.984720352
p_ni:  0.006207309
p_wrong:  0.009072339
Data Source:  BioPlex
KIF11
Tchem
Novelty:  0.00170673
Score:  0.996
Data Source:  STRINGDB
TPX2
Tbio
Novelty:  0.00435921
Score:  0.996
Data Source:  STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.993
Data Source:  STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
Score:  0.993
Data Source:  STRINGDB
CENPE
Tchem
Novelty:  0.00458125
Score:  0.992
Data Source:  STRINGDB
KIF2C
Tbio
Novelty:  0.00498643
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
60.5
1
1
0
1.5
60.5
pulse pressure measurement
1
1
1
50.6
pulse pressure measurement
1
1
1
50.6
macrophage inflammatory protein 1b measurement
1
2
2
49.2
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
60.5
0
1.5
60.5
pulse pressure measurement
1
50.6
pulse pressure measurement
1
50.6
macrophage inflammatory protein 1b measurement
2
49.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 15
VGNC:11423
460310
Macaque
kinesin family member 15
714704
Mouse
MGI:1098258
209737
Rat
RGD:727790
353302
Dog
kinesin family member 15
VGNC:42384
476656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 15
Macaque
kinesin family member 15
Mouse
Rat
Dog
kinesin family member 15
Publication Statistics
PubMed Score 77.30
PubMed score by year
PubTator Score 21.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title