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Tbio
KIF14
Kinesin-like protein KIF14

Protein Summary
Description
Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367350
  • ENSP00000356319
  • ENSG00000118193
  • ENST00000614960
  • ENSP00000483069

Symbol
  • KIAA0042
  • MKS12
  • MCPH20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.97
protein domain
0.85
histone modification site profile
0.84
protein complex
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.92   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.92   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (189)
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.999999093
p_ni:  9.07e-7
Score:  0.705
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999996259
p_ni:  0.000003741
Data Source:  BioPlex
PDPN
Tbio
Novelty:  0.00024118
p_int:  0.999991791
p_ni:  0.000008209
Data Source:  BioPlex
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999988752
p_ni:  0.000011248
Data Source:  BioPlex
CCDC89
Tdark
Novelty:  0.62754711
p_int:  0.999987543
p_ni:  0.000012457
Score:  0.473
Data Source:  BioPlex,STRINGDB
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.999979457
p_ni:  0.000020543
Score:  0.198
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999976879
p_ni:  0.000023121
Score:  0.257
Data Source:  BioPlex,STRINGDB
GORASP2
Tbio
Novelty:  0.02121907
p_int:  0.999968493
p_ni:  0.000031507
Score:  0.554
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.999692032
p_ni:  0.000307968
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.999011658
p_ni:  0.000988342
Score:  0.168
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate CIT
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate CIT
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
30.2
heel bone mineral density
2
1
3
13.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
30.2
heel bone mineral density
3
13.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 14
VGNC:1286
457610
Mouse
MGI:1098226
381293
Rat
RGD:1310650
360849
Dog
kinesin family member 14
VGNC:42383
490248
Horse
kinesin family member 14
VGNC:19394
100146944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 14
Mouse
Rat
Dog
kinesin family member 14
Horse
kinesin family member 14
Publication Statistics
PubMed Score 58.92
PubMed score by year
PubTator Score 32.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title