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Tbio
KIF13A
Kinesin-like protein KIF13A

Protein Summary
Description
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259711
  • ENSP00000259711
  • ENSG00000137177
  • ENST00000378814
  • ENSP00000368091
  • ENST00000378826
  • ENSP00000368103
  • ENST00000378843
  • ENSP00000368120
  • ENST00000502704
  • ENSP00000425453

Symbol
  • RBKIN
  • RBKIN
  • bA500C11.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.97
transcription factor perturbation
0.96
cellular component
0.77
small molecule perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.27   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.27   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
AP1S3
Tbio
Novelty:  0.14425094
p_int:  0.99999999
p_ni:  9e-9
Data Source:  BioPlex
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.999999894
p_ni:  1.05e-7
p_wrong:  1e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999846
p_ni:  9.7e-8
p_wrong:  5.7e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999987573
p_ni:  0.000012388
p_wrong:  3.9e-8
Score:  0.304
Data Source:  BioPlex,STRINGDB
CCT8
Tbio
Novelty:  0.03168289
Score:  0.901
Data Source:  STRINGDB
TCP1
Tbio
Novelty:  0.00395241
Score:  0.9
Data Source:  STRINGDB
CCT3
Tbio
Novelty:  0.01642521
Score:  0.9
Data Source:  STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
Score:  0.9
Data Source:  STRINGDB
CCT2
Tbio
Novelty:  0.01967139
Score:  0.9
Data Source:  STRINGDB
CCT7
Tbio
Novelty:  0.02247038
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
35
neutrophil percentage of leukocytes
1
1
1
30.2
Abdominal symptom
1
1
0
1.9
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
35
neutrophil percentage of leukocytes
1
30.2
Abdominal symptom
0
1.9
5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 13A
VGNC:3261
471862
Macaque
kinesin family member 13A
704126
Mouse
MGI:1098264
16553
Rat
RGD:1307825
308173
Dog
kinesin family member 13A
VGNC:42381
610516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 13A
Macaque
kinesin family member 13A
Mouse
Rat
Dog
kinesin family member 13A
Publication Statistics
PubMed Score 20.27
PubMed score by year
PubTator Score 11.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title