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Tdark
KIAA1586
E3 SUMO-protein ligase KIAA1586

Protein Summary
Description
E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370733
  • ENSP00000359768
  • ENSG00000168116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
histone modification site profile
0.62
tissue sample
0.56
cell line
0.52
virus perturbation
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.8   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.8   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.999997868
p_ni:  0.000002132
Data Source:  BioPlex
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.999969128
p_ni:  0.000030867
p_wrong:  6e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.999739149
p_ni:  0.000255534
p_wrong:  0.000005316
Data Source:  BioPlex
P2RX2
Tchem
Family:  IC
Novelty:  0.00241146
p_int:  0.999676872
p_ni:  0.000322982
p_wrong:  1.46e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.999456311
p_ni:  0.000543508
p_wrong:  1.81e-7
Data Source:  BioPlex
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.801552718
p_ni:  0.006674858
p_wrong:  0.191772424
Data Source:  BioPlex
FLYWCH1
Tdark
Novelty:  0.45235856
Score:  0.652
Data Source:  STRINGDB
OR1C1
Tdark
Family:  oGPCR
Novelty:  5.8313082
Score:  0.621
Data Source:  STRINGDB
BEND6
Tdark
Novelty:  0.51791044
Score:  0.615
Data Source:  STRINGDB
FAM89B
Tbio
Novelty:  0.10306021
Score:  0.587
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein sumoylation.
Name
Explore in Pharos
Explore in Source
Protein modification; protein sumoylation.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIAA1586
VGNC:52014
463201
Horse
KIAA1586
VGNC:19385
100069975
Opossum
E3 SUMO-protein ligase KIAA1586
100617887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIAA1586
Horse
KIAA1586
Opossum
E3 SUMO-protein ligase KIAA1586
Publication Statistics
PubMed Score 0.80
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title